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CCL14 Predicts Oliguria and Dialysis Requirement in Patients with Moderate to Severe Acute Kidney Injury.
Demirjian, Sevag; Chawla, Lakhmir; Davison, Danielle; Forni, Lui G; Heung, Michael; Hoste, Eric A J; Koyner, Jay; Kampf, J Patrick; Kwan, Thomas; McPherson, Paul; Kellum, John A.
Afiliación
  • Demirjian S; Department of Kidney Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
  • Chawla L; Department of Medicine, Veterans Affairs Medical Center, San Diego, California, USA.
  • Davison D; Departments of Anesthesiology and Critical Care Medicine, George Washington University, Washington, District of Columbia, USA.
  • Forni LG; Department of Intensive Care, Royal Surrey Hospital, Guildford, UK.
  • Heung M; Department of Clinical and Experimental Medicine, Faculty of Health Sciences, University of Surrey, Guildford, UK.
  • Hoste EAJ; Division of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Koyner J; Intensive Care Unit, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University, Ghent, Belgium.
  • Kampf JP; Research Foundation-Flanders (FWO), Brussels, Belgium.
  • Kwan T; Section of Nephrology, University of Chicago, Chicago, Illinois, USA.
  • McPherson P; Astute Medical Inc. (a bioMérieux company), San Diego, California, USA.
  • Kellum JA; Astute Medical Inc. (a bioMérieux company), San Diego, California, USA.
Blood Purif ; 53(7): 548-556, 2024.
Article en En | MEDLINE | ID: mdl-38636476
ABSTRACT

INTRODUCTION:

AKI is a frequent complication of critical illness and portends poor outcome. CCL14 is a validated predictor of persistent severe AKI in critically ill patients. We examined the association of CCL14 with urine output within 48 h.

METHODS:

In pooled data from 2 studies of critically ill patients with KDIGO stage 2-3 AKI, CCL14 was measured by NEPHROCLEAR™ CCL14 Test on the Astute 140® Meter (low, intermediate, and high categories [1.3 and 13 ng/mL]). Average hourly urine output over 48 h, stage 3 AKI per urine output criterion on day 2, and composite of dialysis or death within 7 days were examined using multivariable mixed and logistic regression models.

RESULTS:

Of the 497 subjects with median age of 65 (56-74) years, 49% (242/497) were on diuretics. CCL14 concentration was low in 219 (44%), intermediate in 217 (44%), and high in 61 (12%) patients. In mixed regression analysis, hourly urine output over time was different within each CCL14 risk category based on diuretic use due to significant three-way interaction (p < 0.001). In logistic regression analysis, CCL14 risk category was independently associated with low urine output on day 2 per KDIGO stage 3 (adjusted for diuretic use and baseline clinical variables), and composite of dialysis or death within 7 days (adjusted for urine output within 48 h of CCL14 measurement).

CONCLUSIONS:

CCL14 measured in patients with moderate to severe AKI is associated with urine output trajectory within 48 h, oliguria on day 2, and dialysis within 7 days.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oliguria / Diálisis Renal / Lesión Renal Aguda Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Blood Purif Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oliguria / Diálisis Renal / Lesión Renal Aguda Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Blood Purif Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza