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Association between aneuploidy screening analytes and adverse outcomes in twin gestations.
Yamasato, Kelly; Ono, Aiwa.
Afiliación
  • Yamasato K; Department of Obstetrics, Gynecology, and Women's Health, University of Hawai'i at Manoa John A Burns School of Medicine, Honolulu, HI, USA.
  • Ono A; Department of Obstetrics, Gynecology, and Women's Health, University of Hawai'i at Manoa John A Burns School of Medicine, Honolulu, HI, USA.
J Perinat Med ; 52(6): 586-590, 2024 Jul 26.
Article en En | MEDLINE | ID: mdl-38634781
ABSTRACT

OBJECTIVES:

To evaluate associations between serum analytes used for genetic screening and obstetric complications among twin pregnancies.

METHODS:

This cohort included twins delivered at a tertiary care hospital from 2009 to 2017. Abnormal levels of pregnancy associated plasma protein (PAPP-A), first and second trimester human chorionic gonadotropin (hCG), alpha fetoprotein (AFP), estriol, and inhibin, reported as multiples of the median (MoM), were defined as <5 %ile or >95 %ile for our cohort. Associations between abnormal analytes and preterm delivery, small for gestational age, and pregnancy-associated hypertension were calculated using Fisher's exact test.

RESULTS:

A total of 357 dichorionic/diamniotic and 123 monochorionic/diamniotic twins were included. Among dichorionic/diamniotic twins, elevated AFP (>3.70 MoM) was associated with increased preterm delivery <34 weeks (44.4 vs. 16.5 %, p=0.007), while elevated inhibin (>4.95 MoM) was associated with increased preterm delivery<37 weeks (94.1 vs. 58.8 %, p=0.004). For monochorionic/diamniotic twins, elevated inhibin (>6.34 MoM) was associated increased preterm delivery <34 weeks (66.7 vs. 24.8 %, p=0.04) and hypertension (66.7 vs. 21.4 %, p=0.03).

CONCLUSIONS:

Selected abnormal analyte levels were associated with increased rates of adverse outcomes in twin pregnancies, which differed by chorionicity. Our findings assist providers in interpreting abnormal analyte levels in twin pregnancies and may help to identify those at increased risk for adverse outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alfa-Fetoproteínas / Nacimiento Prematuro / Embarazo Gemelar / Inhibinas / Aneuploidia Límite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Revista: J Perinat Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alfa-Fetoproteínas / Nacimiento Prematuro / Embarazo Gemelar / Inhibinas / Aneuploidia Límite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Revista: J Perinat Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania