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Evaluation of the effect of Nigella sativa oil on the outcome of missed abortion in women: A randomized double-blind clinical trial.
Mohammadi, Belgheis; Nazari Robati, Leila; Tavakol, Zeinab; Movahhed, Mina.
Afiliación
  • Mohammadi B; Clinical Research Development Unit, Hajar Hospital Shahrekord University of Medical Sciences Shahrekord Iran.
  • Nazari Robati L; Department of Medicine, Tehran Branch Islamic Azad University Tehran Iran.
  • Tavakol Z; Community-Oriented Nursing Midwifery Research Center, Nursing and Midwifery School Shahrekord University of Medical Sciences Shahrekord Iran.
  • Movahhed M; Department of Traditional Medicine, School of Traditional Medicine Shahid Beheshti University of Medical Sciences Tehran Iran.
Health Sci Rep ; 7(4): e2029, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38633734
ABSTRACT
Background and

Aim:

Due to the concern about the side effects of chemical drugs and their ineffectiveness, the use of natural compounds as alternatives or complementary therapies has received increasing attention. The purpose of this study was to investigate the effect of Nigella sativa oil on the outcome of missed abortion.

Methods:

In this double-blind clinical trial, 70 nulliparous pregnant women referred to Hajar Hospital and Imam Ali clinics of Shahrekord and had missed abortion before the 12-week gestational age were selected and randomly divided into two interventions and control groups. The intervention group received 5 g of Nigella sativa oil alone daily for up to 3 days and the control group received a placebo. In case of nonresponse, 3 days after the last dose of medication or placebo, 800 µg of misoprostol (vaginal) were used. Data were analyzed by SPSS software. The chi-square test, Fisher's exact test, independent t-test and paired t-test were used for analytical statistics.

Results:

According to the results, 18 cases (51.4%) in the intervention group and seven cases (20%) in the control group showed complete evacuation of uterine contents which had a significant difference (p < 0.05). The frequency of vagina physical examination and type of hemorrhage did not show any significant difference between the two groups before and after the intervention. After the intervention, human chorionic gonadotropin (HCG) was significantly decreased in the intervention group but did not change in the control group (p < 0.05). The frequency of adverse events in the intervention group was three (8.6%) and in the control group was one (2.9%) which had no significant difference.

Conclusion:

Nigella sativa improves the outcome of missed abortion by reducing HCG and facilitating cervix dilatation and delivery of uterine contents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Health Sci Rep Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Health Sci Rep Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos