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C-reactive protein-complement factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration.
Giralt, Lena; Figueras-Roca, Marc; Eguileor, Beatriz De Luis; Romero, Barbara; Zarranz-Ventura, Javier; Alforja, Socorro; Santiago, Francisca; Bolaños, Jennifer; Lozano, Francisco; Dotti-Boada, Marina; Sala-Puigdollers, Anna; Dura, Paula; Izquierdo-Serra, Jordi; Valero, Oliver; Adan, Alfredo; Fonollosa, Alex; Molins, Blanca.
Afiliación
  • Giralt L; Institut Clínic d'Oftalmologia (ICOF), Hospital Clínic, Barcelona, Spain.
  • Figueras-Roca M; Department of Ophthalmology, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country, Barakaldo, Spain.
  • Eguileor BL; Institut Clínic d'Oftalmologia (ICOF), Hospital Clínic, Barcelona, Spain.
  • Romero B; Group of Ocular Inflammation: Clinical and Experimental Studies, Institut d'Investigacions Biomèdiques Agustí Pi I Sunyer (IDIBAPS), Barcelona, Spain.
  • Zarranz-Ventura J; Department of Ophthalmology, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country, Barakaldo, Spain.
  • Alforja S; Institut Clínic d'Oftalmologia (ICOF), Hospital Clínic, Barcelona, Spain.
  • Santiago F; Institut Clínic d'Oftalmologia (ICOF), Hospital Clínic, Barcelona, Spain.
  • Bolaños J; Group of Ocular Inflammation: Clinical and Experimental Studies, Institut d'Investigacions Biomèdiques Agustí Pi I Sunyer (IDIBAPS), Barcelona, Spain.
  • Lozano F; Institut Clínic d'Oftalmologia (ICOF), Hospital Clínic, Barcelona, Spain.
  • Dotti-Boada M; Group of Ocular Inflammation: Clinical and Experimental Studies, Institut d'Investigacions Biomèdiques Agustí Pi I Sunyer (IDIBAPS), Barcelona, Spain.
  • Sala-Puigdollers A; Servei d'Immunologia, Centre de Diagnostic Biomèdic, Hospital Clínic Barcelona, Barcelona, Spain.
  • Dura P; Servei d'Immunologia, Centre de Diagnostic Biomèdic, Hospital Clínic Barcelona, Barcelona, Spain.
  • Izquierdo-Serra J; Servei d'Immunologia, Centre de Diagnostic Biomèdic, Hospital Clínic Barcelona, Barcelona, Spain.
  • Valero O; Group of Immunoreceptors of the Innate and Adaptive Systems, Institut d'Investigacions Biomèdiques Agustí Pi I Sunyer (IDIBAPS), Barcelona, Spain.
  • Adan A; Departament de Biomedicina, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain.
  • Fonollosa A; Institut Clínic d'Oftalmologia (ICOF), Hospital Clínic, Barcelona, Spain.
  • Molins B; Institut Clínic d'Oftalmologia (ICOF), Hospital Clínic, Barcelona, Spain.
Front Immunol ; 15: 1330913, 2024.
Article en En | MEDLINE | ID: mdl-38633250
ABSTRACT

Purpose:

To determine and compare the serum levels of complement Factor H (FH), monomeric C-Reactive Protein (mCRP) and pentameric C-Reactive protein (pCRP) in patients with age-related macular degeneration (AMD) and to correlate them with clinical, structural and functional parameters.

Methods:

Cross-sectional observational study. One hundred thirty-nine individuals (88 patients and 51 healthy controls) from two referral centers were included and classified into three groups early or intermediate AMD (n=33), advanced AMD (n=55), and age and sex matched healthy controls (n=51). Serum levels of FH, mCRP, and pCRP were determined and correlated with clinical and imaging parameters.

Results:

Patients with intermediate AMD presented FH levels significantly lower than controls [186.5 (72.1-931.8) µg/mL vs 415.2 (106.1-1962.2) µg/mL; p=0.039] and FH levels <200 µg/mL were associated with the presence of drusen and pigmentary changes in the fundoscopy (p=0.002). While no differences were observed in pCRP and mCRP levels, and mCRP was only detected in less than 15% of the included participants, women had a significantly higher detection rate of mCRP than men (21.0% vs. 3.8%, p=0.045). In addition, the ratio mCRP/FH (log) was significantly lower in the control group compared to intermediate AMD (p=0.031). Visual acuity (p<0.001), macular volume (p<0.001), and foveal thickness (p=0.034) were significantly lower in the advanced AMD group, and choroidal thickness was significantly lower in advanced AMD compared to early/intermediate AMD (p=0.023).

Conclusion:

Intermediate AMD was associated in our cohort with decreased serum FH levels together with increased serum mCRP/FH ratio. All these objective serum biomarkers may suggest an underlying systemic inflammatory process in early/intermediate AMD patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína C-Reactiva / Factor H de Complemento / Degeneración Macular Límite: Female / Humans / Male Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína C-Reactiva / Factor H de Complemento / Degeneración Macular Límite: Female / Humans / Male Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza