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Ameliorative effect of Odontonema cuspidatum extract against testicular damage induced by sodium nitrite in rats.
Elsawy, Nesma H; Elshazly, Samir A; Elkattawy, Azza M; Nasr, Nasr E; Almadaly, Essam A; Refaey, Mohamed S; Kahilo, Khaled A; Assas, Mona; Abdo, Walied; Hashem, Aml S; Abouzed, Tarek K; Dorghamm, Doaa Abdullah.
Afiliación
  • Elsawy NH; Department of Biochemistry, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
  • Elshazly SA; Department of Biochemistry, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
  • Elkattawy AM; Department of Biochemistry, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
  • Nasr NE; Department of Biochemistry, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
  • Almadaly EA; Department of Theriogenology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
  • Refaey MS; Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koom, Egypt.
  • Kahilo KA; Department of Biochemistry, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
  • Assas M; Fish Processing and Biotechnology Department, Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, Kafrelsheikh, Egypt.
  • Abdo W; Department of Veterinary Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
  • Hashem AS; Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
  • Abouzed TK; Department of Biochemistry, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
  • Dorghamm DA; Department of Biochemistry, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
Open Vet J ; 14(1): 304-315, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38633197
ABSTRACT

Background:

Sodium nitrite (NaNO2) is a chemical substance used to enhance taste, add color, and keep food products fit for consumption for a longer time. NaNO2 gives rise to a negative adverse effect on male reproductive function. Odontonema cuspidatum (OC) is a natural plant that possesses antioxidant capacity.

Aim:

Our research evaluates the potential beneficial effect of OC extract on the harmful effects caused by NaNO2 on the testicular tissue and sperm characteristics of male rats.

Methods:

Four groups with a total of forty rats the control, the NaNO2-received group, the OC-administered group, and the fourth group received both NaNO2 and OC. All groups were administered daily for two months. Sperm characteristics, testicular antioxidant status, qRT-PCR, and histopathological changes were evaluated.

Results:

Coadministration of NaNO2 and OC, in comparison with NaNO2 alone, contributed to a notable enhancement in acrosomal integrity, decreasing sperm abnormalities and restoring serum testosterone levels. Moreover, such coadministration reduced the oxidative stress marker, malondialdehyde (MDA), and increased superoxide dismutase (SOD) in testicular tissue, lowering TNF-α gene expression, and increasing the expression of P450scc and StAR genes. In addition, the NaNO2 and OC combination decreased the testicular histopathological changes and the Caspase-3 and Proliferating cell nuclear antigen (PCNA) immunoexpression in seminiferous tubules compared with the NaNO2 group.

Conclusion:

The extract of OC exhibited the ability to decrease oxidative stress and ameliorate the detrimental effects caused by NaNO2.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nitrito de Sodio / Antioxidantes Límite: Animals Idioma: En Revista: Open Vet J Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Libia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nitrito de Sodio / Antioxidantes Límite: Animals Idioma: En Revista: Open Vet J Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Libia