Your browser doesn't support javascript.
loading
pH-sensitive release of nitric oxide gas using peptide-graphene co-assembled hybrid nanosheets.
Tabish, Tanveer A; Xu, Jiamin; Campbell, Christopher K; Abbas, Manzar; Myers, William K; Didwal, Pravin; Carugo, Dario; Xie, Fang; Crabtree, Mark J; Stride, Eleanor; Lygate, Craig A.
Afiliación
  • Tabish TA; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation (BHF) Centre of Research Excellence, University of Oxford, Oxford, OX3 7BN, United Kingdom. Electronic address: tanveer.tabish@cardiov.ox.ac.uk.
  • Xu J; Department of Materials and London Centre for Nanotechnology, Imperial College London, London, SW7 2AZ, United Kingdom.
  • Campbell CK; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), The Botnar Research Centre, University of Oxford, Oxford, OX3 7LD, United Kingdom.
  • Abbas M; Department of Chemistry, Khalifa University of Science and Technology, P.O. Box, 127788, Abu Dhabi, United Arab Emirates.
  • Myers WK; Centre for Advanced Electron Spin Resonance (CAESR), Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3QR, United Kingdom.
  • Didwal P; Department of Materials, University of Oxford, Parks Road, Oxford, OX1 3PH, United Kingdom.
  • Carugo D; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), The Botnar Research Centre, University of Oxford, Oxford, OX3 7LD, United Kingdom.
  • Xie F; Department of Materials and London Centre for Nanotechnology, Imperial College London, London, SW7 2AZ, United Kingdom.
  • Crabtree MJ; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation (BHF) Centre of Research Excellence, University of Oxford, Oxford, OX3 7BN, United Kingdom; Department of Biochemical Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, GU2 7XH
  • Stride E; Institute of Biomedical Engineering (IBME), Department of Engineering Science, University of Oxford, Oxford, OX3 7LD, United Kingdom.
  • Lygate CA; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation (BHF) Centre of Research Excellence, University of Oxford, Oxford, OX3 7BN, United Kingdom.
Nitric Oxide ; 147: 42-50, 2024 Jun 01.
Article en En | MEDLINE | ID: mdl-38631610
ABSTRACT
Nitric oxide (NO) donating drugs such as organic nitrates have been used to treat cardiovascular diseases for more than a century. These donors primarily produce NO systemically. It is however sometimes desirable to control the amount, location, and time of NO delivery. We present the design of a novel pH-sensitive NO release system that is achieved by the synthesis of dipeptide diphenylalanine (FF) and graphene oxide (GO) co-assembled hybrid nanosheets (termed as FF@GO) through weak molecular interactions. These hybrid nanosheets were characterised by using X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, zeta potential measurements, X-ray photoelectron spectroscopy, scanning and transmission electron microscopies. The weak molecular interactions, which include electrostatic, hydrogen bonding and π-π stacking, are pH sensitive due to the presence of carboxylic acid and amine functionalities on GO and the dipeptide building blocks. Herein, we demonstrate that this formulation can be loaded with NO gas with the dipeptide acting as an arresting agent to inhibit NO burst release at neutral pH; however, at acidic pH it is capable of releasing NO at the rate of up to 0.6 µM per minute, comparable to the amount of NO produced by healthy endothelium. In conclusion, the innovative conjugation of dipeptide with graphene can store and release NO gas under physiologically relevant concentrations in a pH-responsive manner. pH responsive NO-releasing organic-inorganic nanohybrids may prove useful for the treatment of cardiovascular diseases and other pathologies.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanoestructuras / Grafito / Óxido Nítrico Límite: Humans Idioma: En Revista: Nitric Oxide Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanoestructuras / Grafito / Óxido Nítrico Límite: Humans Idioma: En Revista: Nitric Oxide Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos