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Statistical techniques to assess publication integrity in groups of randomized trials: a narrative review.
Bolland, Mark J; Avenell, Alison; Grey, Andrew.
Afiliación
  • Bolland MJ; Department of Medicine, University of Auckland, Private Bag 92 019, Auckland 1142, New Zealand; Department of Endocrinology, ADHB, Private Bag 92 024, Auckland 1142, New Zealand. Electronic address: m.bolland@auckland.ac.nz.
  • Avenell A; Health Services Research Unit, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland.
  • Grey A; Department of Medicine, University of Auckland, Private Bag 92 019, Auckland 1142, New Zealand.
J Clin Epidemiol ; 170: 111365, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38631528
ABSTRACT

OBJECTIVES:

To describe statistical tools available for assessing publication integrity of groups of randomized controlled trials (RCTs). STUDY DESIGN AND

SETTING:

Narrative review.

RESULTS:

Freely available statistical tools have been developed that compare the observed distributions of baseline variables with the expected distributions that would occur if successful randomization occurred. For continuous variables, the tools assess baseline means, baseline P values, and the occurrence of identical means and/or standard deviation. For categorical variables, they assess baseline P values, frequency counts for individual or all variables, numbers of trial participants randomized or withdrawing, and compare reported with independently calculated P values. The tools have been used to identify publication integrity concerns in RCTs from individual groups, and performed at an acceptable level in discriminating intentionally fabricated baseline summary data from genuine RCTs. The tools can be used when concerns have been raised about RCT(s) from an individual/group and when the whole body of their work is being examined, when conducting systematic reviews, and could be adapted to aid screening of RCTs at journal submission.

CONCLUSION:

Statistical tools are useful for the assessment of publication integrity of groups of RCTs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensayos Clínicos Controlados Aleatorios como Asunto Límite: Humans Idioma: En Revista: J Clin Epidemiol Asunto de la revista: EPIDEMIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensayos Clínicos Controlados Aleatorios como Asunto Límite: Humans Idioma: En Revista: J Clin Epidemiol Asunto de la revista: EPIDEMIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos