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Angiogenesis-related immune response may be the prelude to the syndesmophyte formation in Ankylosing spondylitis.
Cai, Chunmei; Huang, Yuye; Li, Liyan; Miu, Kai Kei; Wang, Zhangting; Deng, Yujie; Cai, Yanzhen; Li, Jinxiu; Wu, Liang; Zhu, Hepeng; Gao, Yang; Chen, Jun; Xiao, Wende; Lu, Li.
Afiliación
  • Cai C; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Huang Y; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Li L; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Miu KK; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong SAR, China.
  • Wang Z; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong SAR, China.
  • Deng Y; Guangzhou National Laboratory, Guangzhou, China.
  • Cai Y; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Li J; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China.
  • Wu L; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China.
  • Zhu H; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Gao Y; Department of Pharmacy & State Key Laboratory of Ophthalmology, Zhongshan Ophthalmological Center, Sun Yat-sen University, Guangzhou 510060, China.
  • Chen J; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Xiao W; Guangzhou First People's Hospital, Spine Surgery, Guangzhou 510180, China. Electronic address: eyxiaowende@scut.edu.cn.
  • Lu L; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: luli@gdpu.edu.cn.
Int Immunopharmacol ; 133: 112040, 2024 May 30.
Article en En | MEDLINE | ID: mdl-38631220
ABSTRACT

BACKGROUND:

Ankylosing spondylitis (AS) is a chronic autoimmune arthritis that mainly affects spine joints. To date, the pathogenesis of AS remains unclear, although immune cells and innate immune response cytokines have been suggested to be crucial players.

METHODS:

By adopting a single-cell RNA sequencing approach in the AS cynomolgus model, we profiled and characterized PBMC proportions along disease progression.

RESULTS:

Here, our primary focus was on the activation of an immune cascade-initiating lymphocyte subtype known as CD4+CXCR5+ T follicular helper (Tfh) cells. These Tfhs demonstrated a localized residence in AS bone lesion as an ectopic lymphoid structure. Moreover, Tfhs would serve as an upstream initiator for a pro-angiogenic cascade. Then, an expansion in CD14+ monocytes and DC cells subsets resulted in enhanced expression of angiogenesis genes in these AS cynomolgus monkeys. With a confirmed higher abundance of TNF-α accompanying H-type vascular invasion in the osteophytic region, pronounced expansion of Tfhs at such lesion site signaling for monocytes and DCs intrusion is considered as the prelude to the characteristic angiogenic bony outgrowth in AS known as syndesmophytes.

CONCLUSIONS:

We explored the intimate relationship between local inflammation and bone formation in AS from the perspective of nascent vascularisation. Hence, our study lays the foundation for elucidating a unified AS pathogenesis through the immune-angiogenesis-osteogenesis axis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espondilitis Anquilosante / Macaca fascicularis / Neovascularización Patológica Límite: Animals / Humans / Male Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espondilitis Anquilosante / Macaca fascicularis / Neovascularización Patológica Límite: Animals / Humans / Male Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos