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Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.
Noda, Aoi; Obara, Taku; Shirota, Matsuyuki; Ueno, Fumihiko; Matsuzaki, Fumiko; Hatanaka, Rieko; Obara, Ryo; Morishita, Kei; Shinoda, Genki; Orui, Masatsugu; Murakami, Keiko; Ishikuro, Mami; Kuriyama, Shinichi.
Afiliación
  • Noda A; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryou-Cho, Aoba-Ku, Sendai, Miyagi, 980-8573, Japan.
  • Obara T; Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
  • Shirota M; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Miyagi, Japan.
  • Ueno F; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryou-Cho, Aoba-Ku, Sendai, Miyagi, 980-8573, Japan. obara-t@hosp.tohoku.ac.jp.
  • Matsuzaki F; Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. obara-t@hosp.tohoku.ac.jp.
  • Hatanaka R; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Miyagi, Japan. obara-t@hosp.tohoku.ac.jp.
  • Obara R; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryou-Cho, Aoba-Ku, Sendai, Miyagi, 980-8573, Japan.
  • Morishita K; Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
  • Shinoda G; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryou-Cho, Aoba-Ku, Sendai, Miyagi, 980-8573, Japan.
  • Orui M; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryou-Cho, Aoba-Ku, Sendai, Miyagi, 980-8573, Japan.
  • Murakami K; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryou-Cho, Aoba-Ku, Sendai, Miyagi, 980-8573, Japan.
  • Ishikuro M; Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
  • Kuriyama S; Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Eur J Clin Pharmacol ; 80(8): 1171-1180, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38630193
ABSTRACT

PURPOSE:

To elucidate the status of medication use among pregnant women in Japan, by means of a multigenerational genome and birth cohort study the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study).

METHODS:

Questionnaires were distributed to pregnant women participating in the TMM BirThree Cohort Study (from July 2013 to March 2017) around 12 weeks (early pregnancy) and 26 weeks (middle pregnancy). We analysed medication use over three periods (1) 12 months prior to pregnancy diagnosis, (2) the period between pregnancy diagnosis and around week 12 of pregnancy, and (3) post around week 12 of pregnancy.

RESULTS:

In total, 19,297 women were included in the analysis. The proportion of pregnant women using medications was 49.0% prior to pregnancy diagnosis, 52.1% from diagnosis to week 12, and 58.4% post week 12 of pregnancy. The most frequently prescribed medications were loxoprofen sodium hydrate (5.5%) prior to pregnancy diagnosis, magnesium oxide (5.9%) from diagnosis to week 12, and ritodrine hydrochloride (10.5%) post week 12 of pregnancy. The number of women who used suspected teratogenic medications during early pregnancy was 96 prior to pregnancy diagnosis, 48 from diagnosis to week 12, and 54 post week 12 of pregnancy.

CONCLUSION:

We found that ~ 50% of the pregnant women used medications before and during pregnancy and some took potential teratogenic medications during pregnancy. In birth genomic cohort study, it is expected that investigations into the safety and effectiveness of medications used during pregnancy will advance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Eur J Clin Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Eur J Clin Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania