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Repurposing approved drugs as potential efflux pump inhibitors in multidrug-resistant Pseudomonas aeruginosa.
de Melo Guedes, Gláucia Morgana; Pereira, Vinicius Carvalho; Freitas, Alyne Soares; Honório de Souza, Paulo Roberto; Chacon Parra, Aura Lucia; Brasil, Jaiane Alves; de Medeiros Guedes, Rodrigo Fonseca; Pereira de Sousa, Paulo César; Aguiar Cordeiro, Rossana de; Gadelha Rocha, Marcos Fábio; Costa Sidrim, José Júlio; Souza Collares Maia Castelo Branco, Débora de.
Afiliación
  • de Melo Guedes GM; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil.
  • Pereira VC; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Laboratory of Emerging and Reemerging Pathogens, Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil.
  • Freitas AS; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil.
  • Honório de Souza PR; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil.
  • Chacon Parra AL; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil.
  • Brasil JA; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil.
  • de Medeiros Guedes RF; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil.
  • Pereira de Sousa PC; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil.
  • Aguiar Cordeiro R; Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Ceará, 60430-372, Brazil.
  • Gadelha Rocha MF; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Laboratory of Emerging and Reemerging Pathogens, Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil.
  • Costa Sidrim JJ; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Laboratory of Emerging and Reemerging Pathogens, Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil.
  • Souza Collares Maia Castelo Branco D; Postgraduate Program in Veterinary Sciences, School of Veterinary, State University of Ceará, Fortaleza, Ceará, 60714-903, Brazil.
Future Microbiol ; 19(6): 495-508, 2024.
Article en En | MEDLINE | ID: mdl-38629920
ABSTRACT

Aim:

To evaluate the action of promethazine, fluoxetine and carbonyl cyanide 3-chlorophenylhydrazone as efflux pump inhibitors (EPIs) against multidrug-resistant Pseudomonas aeruginosa.

Methods:

The effect of the compounds was evaluated in planktonic cells and bacterial biofilms. Accumulation tests were performed with ethidium bromide to prove their action as EPIs. Then, they were associated with antimicrobials.

Results:

Effect on planktonic cells and biofilms was found. Assays with ethidium bromide indicate their action as EPIs. Significant reductions in the metabolic activity of biofilms were observed after the association with the antimicrobials, especially for meropenem.

Conclusion:

It is possible to prove the action of these compounds as EPIs for P. aeruginosa and demonstrate the relevance of efflux pumps in antimicrobial resistance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Pruebas de Sensibilidad Microbiana / Biopelículas / Farmacorresistencia Bacteriana Múltiple / Reposicionamiento de Medicamentos / Antibacterianos Límite: Humans Idioma: En Revista: Future Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Pruebas de Sensibilidad Microbiana / Biopelículas / Farmacorresistencia Bacteriana Múltiple / Reposicionamiento de Medicamentos / Antibacterianos Límite: Humans Idioma: En Revista: Future Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido