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Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes.
Hivert, Marie-France; White, Frédérique; Allard, Catherine; James, Kaitlyn; Majid, Sana; Aguet, François; Ardlie, Kristin G; Florez, Jose C; Edlow, Andrea G; Bouchard, Luigi; Jacques, Pierre-Étienne; Karumanchi, S Ananth; Powe, Camille E.
Afiliación
  • Hivert MF; Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA. MHIVERT@mgb.org.
  • White F; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. MHIVERT@mgb.org.
  • Allard C; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Sherbrooke, Quebec, Canada. MHIVERT@mgb.org.
  • James K; Département de Biologie, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
  • Majid S; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Sherbrooke, Quebec, Canada.
  • Aguet F; Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Ardlie KG; Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
  • Florez JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Edlow AG; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Bouchard L; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Jacques PÉ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Karumanchi SA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Powe CE; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Nat Med ; 30(6): 1689-1695, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38627562
ABSTRACT
Reduced insulin sensitivity (insulin resistance) is a hallmark of normal physiology in late pregnancy and also underlies gestational diabetes mellitus (GDM). We conducted transcriptomic profiling of 434 human placentas and identified a positive association between insulin-like growth factor binding protein 1 gene (IGFBP1) expression in the placenta and insulin sensitivity at ~26 weeks gestation. Circulating IGFBP1 protein levels rose over the course of pregnancy and declined postpartum, which, together with high gene expression levels in our placenta samples, suggests a placental or decidual source. Higher circulating IGFBP1 levels were associated with greater insulin sensitivity (lesser insulin resistance) at ~26 weeks gestation in the same cohort and in two additional pregnancy cohorts. In addition, low circulating IGFBP1 levels in early pregnancy predicted subsequent GDM diagnosis in two cohorts of pregnant women. These results implicate IGFBP1 in the glycemic physiology of pregnancy and suggest a role for placental IGFBP1 deficiency in GDM pathogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Resistencia a la Insulina / Diabetes Gestacional / Proteína 1 de Unión a Factor de Crecimiento Similar a la Insulina Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Resistencia a la Insulina / Diabetes Gestacional / Proteína 1 de Unión a Factor de Crecimiento Similar a la Insulina Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos