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Unresectable biliary tract cancer: Current and future systemic therapy.
Zhang, Danmei; Dorman, Klara; Westphalen, C Benedikt; Haas, Michael; Ormanns, Steffen; Neumann, Jens; Seidensticker, Max; Ricke, Jens; De Toni, Enrico N; Klauschen, Frederick; Algül, Hana; Reisländer, Timo; Boeck, Stefan; Heinemann, Volker.
Afiliación
  • Zhang D; Department of Medicine III, LMU University Hospital, LMU Munich and Comprehensive Cancer Center Munich, Marchioninistr. 15, 81377 Munich, Germany.
  • Dorman K; Department of Medicine III, LMU University Hospital, LMU Munich and Comprehensive Cancer Center Munich, Marchioninistr. 15, 81377 Munich, Germany.
  • Westphalen CB; Department of Medicine III, LMU University Hospital, LMU Munich and Comprehensive Cancer Center Munich, Marchioninistr. 15, 81377 Munich, Germany.
  • Haas M; Department of Medicine III, LMU University Hospital, LMU Munich and Comprehensive Cancer Center Munich, Marchioninistr. 15, 81377 Munich, Germany; Department of Hematology and Oncology, München Klinik Neuperlach, Munich, Germany.
  • Ormanns S; Institute of Pathology, Faculty of Medicine, LMU Munich, Germany; Innpath GmbH, Tirolkliniken, Innsbruck, Austria.
  • Neumann J; Institute of Pathology, Faculty of Medicine, LMU Munich, Germany.
  • Seidensticker M; Department of Radiology, LMU University Hospital, LMU Munich, Germany.
  • Ricke J; Department of Radiology, LMU University Hospital, LMU Munich, Germany.
  • De Toni EN; Department of Medicine II, LMU University Hospital, LMU Munich, Germany; Boehringer Ingelheim, Clinical Program Lead, Bingerstrasse 137, Ingelheim am Rhein 55218, Germany.
  • Klauschen F; Institute of Pathology, Faculty of Medicine, LMU Munich, Germany.
  • Algül H; Comprehensive Cancer Center Munich TUM, Institute for Tumor Metabolism, Technical University of Munich, Munich, Germany.
  • Reisländer T; SERVIER Deutschland GmbH, Medical Affairs, Elsenheimerstr. 53, 80687 Munich, Germany.
  • Boeck S; Department of Medicine III, LMU University Hospital, LMU Munich and Comprehensive Cancer Center Munich, Marchioninistr. 15, 81377 Munich, Germany; Department of Hematology and Oncology, München Klinik Neuperlach, Munich, Germany.
  • Heinemann V; Department of Medicine III, LMU University Hospital, LMU Munich and Comprehensive Cancer Center Munich, Marchioninistr. 15, 81377 Munich, Germany. Electronic address: volker.heinemann@med.uni-muenchen.de.
Eur J Cancer ; 203: 114046, 2024 May.
Article en En | MEDLINE | ID: mdl-38626513
ABSTRACT
For decades, treatment of advanced biliary tract cancer (BTC) was confined to the use of chemotherapy. In recent years however, the number of therapeutic options available for patients with unresectable BTC have drastically increased, with immunotherapy and targeted treatment gradually joining the ranks of guideline-recommended treatment regimens. The aim of the present review is to summarise the current knowledge on unresectable BTC focusing on epidemiology, anatomical distribution and current strategies for systemic treatment. We further outline ongoing clinical trials and provide an outlook on future therapeutic interventions. In the realm of gastrointestinal malignancies, the increasing number of systemic treatment options for BTC is finally delivering on the longstanding commitment to personalised oncology. This emphasises the need for considering a comprehensive genomic-based pathology assessment right from the initial diagnosis to fully leverage the expanding array of therapeutic options that have recently become accessible.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Sistema Biliar Límite: Humans Idioma: En Revista: Eur J Cancer Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Sistema Biliar Límite: Humans Idioma: En Revista: Eur J Cancer Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido