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Ciliary muscles contraction leads to axial length extension--The possible initiating factor for myopia.
Meng, Zhao-Yang; Yang, Lin; Zhou, Peng.
Afiliación
  • Meng ZY; Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Yang L; Department of Ophthalmology, Visionly Plus Eye Hospital, Beijing, China.
  • Zhou P; Department of Ophthalmology, Parkway Gleneagles Medical and Surgical Center, Shanghai, China.
PLoS One ; 19(4): e0301844, 2024.
Article en En | MEDLINE | ID: mdl-38626193
ABSTRACT

PURPOSE:

This study aimed to investigate the underlying factors driving the onset of myopia, specifically the role of the ciliary muscle's contraction in the elongation of the axial length of the eye.

METHODS:

The retrospective study was conducted utilizing data from three ophthalmic centers in Shanghai and Beijing. Both Chinese and Caucasian children were involved. The axial length of the subjects' eyes was measured in both relaxed and contracted state of the ciliary muscle. A comprehensive mechanical model was also developed to observe the influence of ciliary muscle contraction on the axial length.

RESULTS:

This study included a sample of 198 right eyes of 198 myopic children. Of these, 97 were male and 101 were female, 126 were of Chinese ethnicity and 72 were Caucasian. The age of onset for myopia ranged from 5.9 to 16.9 years old. The axial length of the eye decreased 0.028 ± 0.007mm following dilation, indicating relaxation of the ciliary muscle (t paired student = 15.16, p = 6.72 x 10-35). In contrast, ciliary muscle contraction resulted in an increase in axial length. Considering proportionality, a significant 90.4% (179 eyes) exhibited a reduced axial length, while a minor 9.6% (19 eyes) demonstrated an increase post-mydriasis. Finite element modeling demonstrated that muscle contraction caused a tension force that transmits towards the posterior pole of the eye, causing it to extend posteriorly.

CONCLUSION:

The contraction of the ciliary muscle leads to an extension of the axial length. This could potentially be the initiating factor for myopia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miopía Límite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miopía Límite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos