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Key Roles of Gli1 and Ihh Signaling in Craniofacial Development.
Sun, Qi; Huang, Jie; Tian, Jingjun; Lv, Changhai; Li, Yanhong; Yu, Siyuan; Liu, Juan; Zhang, Jun.
Afiliación
  • Sun Q; Department of Pediatric Dentistry, School and Hospital of Stomatology, Kunming Medical University, Kunming, Yunnan, Republic of China.
  • Huang J; Yunnan Key Laboratory of Stomatology, Kunming Medical University, Kunming, Yunnan, Republic of China.
  • Tian J; Department of Pediatric Dentistry, School and Hospital of Stomatology, Kunming Medical University, Kunming, Yunnan, Republic of China.
  • Lv C; Yunnan Key Laboratory of Stomatology, Kunming Medical University, Kunming, Yunnan, Republic of China.
  • Li Y; Department of Orthodontics, School and Hospital of Stomatology, Kunming Medical University, Kunming, Yunnan, Republic of China.
  • Yu S; Department of Pediatric Dentistry, School and Hospital of Stomatology, Kunming Medical University, Kunming, Yunnan, Republic of China.
  • Liu J; Department of Preventive Dentistry, School and Hospital of Stomatology, Kunming Medical University, Kunming, Yunnan, Republic of China.
  • Zhang J; Department of Pediatric Dentistry, School and Hospital of Stomatology, Kunming Medical University, Kunming, Yunnan, Republic of China.
Stem Cells Dev ; 33(11-12): 251-261, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38623785
ABSTRACT
The Hedgehog (Hh) signaling pathway orchestrates its influence through a dynamic interplay of Hh proteins, the cell surface receptor Ptch1, Smo, and Gli transcription factors, contributing to a myriad of developmental events. Indian Hedgehog (Ihh) and Gli zinc finger transcription factor 1 (Gli1) play crucial roles in developmental regulation within the Hh signaling pathway. Ihh regulates chondrocyte proliferation, differentiation, and bone formation, impacting the development of cranial bones, cartilage, and the temporomandibular joint (TMJ). Losing Ihh results in cranial bone malformation and decreased ossification and affects the formation of cranial base cartilage unions, TMJ condyles, and joint discs. Gli1 is predominantly expressed during early craniofacial development, and Gli1+ cells are identified as the primary mesenchymal stem cells (MSCs) for craniofacial bones, crucial for cell differentiation and morphogenesis. In addition, a complex mutual regulatory mechanism exists between Gli1 and Ihh, ensuring the normal function of the Hh signaling pathway by directly or indirectly regulating each other's expression levels. And the interaction between Ihh and Gli1 significantly impacts the normal development of craniofacial tissues. This review summarizes the pivotal roles of Gli1 and Ihh in the intricate landscape of mammalian craniofacial development and outlines the molecular regulatory mechanisms and intricate interactions governing the growth of bone and cartilage exhibited by Gli1 and Ihh, which provides new insights into potential therapeutic strategies for related diseases or researches of tissue regeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Proteínas Hedgehog / Proteína con Dedos de Zinc GLI1 Límite: Animals / Humans Idioma: En Revista: Stem Cells Dev Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Proteínas Hedgehog / Proteína con Dedos de Zinc GLI1 Límite: Animals / Humans Idioma: En Revista: Stem Cells Dev Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos