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High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging.
Zhao, Qi; Holt, Abigail; Spritzer, Charles E; DeFrate, Louis E; McNulty, Amy L; Wang, Nian.
Afiliación
  • Zhao Q; Physical Education Institute, Jimei University, Xiamen, China.
  • Holt A; Department of Radiology, Duke University School of Medicine, Durham, NC, USA.
  • Spritzer CE; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, USA.
  • DeFrate LE; Department of Radiology, Duke University School of Medicine, Durham, NC, USA.
  • McNulty AL; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, USA.
  • Wang N; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Quant Imaging Med Surg ; 14(4): 2738-2746, 2024 Apr 03.
Article en En | MEDLINE | ID: mdl-38617143
ABSTRACT

Background:

Diffusion magnetic resonance imaging (MRI) allows for the quantification of water diffusion properties in soft tissues. The goal of this study was to characterize the 3D collagen fiber network in the porcine meniscus using high angular resolution diffusion imaging (HARDI) acquisition with both diffusion tensor imaging (DTI) and generalized q-sampling imaging (GQI).

Methods:

Porcine menisci (n=7) were scanned ex vivo using a three-dimensional (3D) HARDI spin-echo pulse sequence with an isotropic resolution of 500 µm at 7.0 Tesla. Both DTI and GQI reconstruction techniques were used to quantify the collagen fiber alignment and visualize the complex collagen network of the meniscus. The MRI findings were validated with conventional histology.

Results:

DTI and GQI exhibited distinct fiber orientation maps in the meniscus using the same HARDI acquisition. We found that crossing fibers were only resolved with GQI, demonstrating the advantage of GQI over DTI to visualize the complex collagen fiber orientation in the meniscus. Furthermore, the MRI findings were consistent with conventional histology.

Conclusions:

HARDI acquisition with GQI reconstruction more accurately resolves the complex 3D collagen architecture of the meniscus compared to DTI reconstruction. In the future, these technologies have the potential to nondestructively assess both normal and abnormal meniscal structure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Quant Imaging Med Surg Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Quant Imaging Med Surg Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China