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Striatal parvalbumin interneurons are activated in a mouse model of cerebellar dystonia.
Matsuda, Taku; Morigaki, Ryoma; Hayasawa, Hiroaki; Koyama, Hiroshi; Oda, Teruo; Miyake, Kazuhisa; Takagi, Yasushi.
Afiliación
  • Matsuda T; Department of Neurosurgery, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan.
  • Morigaki R; Department of Neurosurgery, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan.
  • Hayasawa H; Department of Advanced Brain Research, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan.
  • Koyama H; Parkinson's Disease and Dystonia Research Center, Tokushima University Hospital, Tokushima 770-8503, Japan.
  • Oda T; Department of Neurosurgery, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan.
  • Miyake K; Department of Neurosurgery, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan.
  • Takagi Y; Department of Advanced Brain Research, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan.
Dis Model Mech ; 17(5)2024 May 01.
Article en En | MEDLINE | ID: mdl-38616770
ABSTRACT
Dystonia is thought to arise from abnormalities in the motor loop of the basal ganglia; however, there is an ongoing debate regarding cerebellar involvement. We adopted an established cerebellar dystonia mouse model by injecting ouabain to examine the contribution of the cerebellum. Initially, we examined whether the entopeduncular nucleus (EPN), substantia nigra pars reticulata (SNr), globus pallidus externus (GPe) and striatal neurons were activated in the model. Next, we examined whether administration of a dopamine D1 receptor agonist and dopamine D2 receptor antagonist or selective ablation of striatal parvalbumin (PV, encoded by Pvalb)-expressing interneurons could modulate the involuntary movements of the mice. The cerebellar dystonia mice had a higher number of cells positive for c-fos (encoded by Fos) in the EPN, SNr and GPe, as well as a higher positive ratio of c-fos in striatal PV interneurons, than those in control mice. Furthermore, systemic administration of combined D1 receptor agonist and D2 receptor antagonist and selective ablation of striatal PV interneurons relieved the involuntary movements of the mice. Abnormalities in the motor loop of the basal ganglia could be crucially involved in cerebellar dystonia, and modulating PV interneurons might provide a novel treatment strategy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Parvalbúminas / Proteínas Proto-Oncogénicas c-fos / Receptores de Dopamina D2 / Cuerpo Estriado / Modelos Animales de Enfermedad / Distonía / Interneuronas Límite: Animals Idioma: En Revista: Dis Model Mech Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Parvalbúminas / Proteínas Proto-Oncogénicas c-fos / Receptores de Dopamina D2 / Cuerpo Estriado / Modelos Animales de Enfermedad / Distonía / Interneuronas Límite: Animals Idioma: En Revista: Dis Model Mech Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido