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The association of caffeine and nandrolone decanoate modulates aversive memory and nociception in rats.
Penna, Daniel Bussinger de Souza; Gumiéro Costa, Samara; Dos Santos-Rodrigues, Alexandre; Pandolfo, Pablo.
Afiliación
  • Penna DBS; Institute of Biomedical Sciences, Program of Biomedical Sciences: Physiology and Pharmacology, Federal Fluminense University, Niteroi, Brazil; Institute of Biology, Program of Neurosciences, Federal Fluminense University, Niteroi, Brazil.
  • Gumiéro Costa S; Institute of Biomedical Sciences, Program of Biomedical Sciences: Physiology and Pharmacology, Federal Fluminense University, Niteroi, Brazil.
  • Dos Santos-Rodrigues A; Institute of Biology, Program of Neurosciences, Federal Fluminense University, Niteroi, Brazil.
  • Pandolfo P; Institute of Biomedical Sciences, Program of Biomedical Sciences: Physiology and Pharmacology, Federal Fluminense University, Niteroi, Brazil; Institute of Biology, Program of Neurosciences, Federal Fluminense University, Niteroi, Brazil. Electronic address: pablopandolfo@id.uff.br.
Brain Res ; 1837: 148937, 2024 Aug 15.
Article en En | MEDLINE | ID: mdl-38615923
ABSTRACT
Caffeine and anabolic-androgenic steroids (AAS) are commonly used to improve muscle mass and athletic performance. Nandrolone Decanoate (ND) is one of the most abused AAS worldwide, leading to behavioral changes in both humans and rodents. Caffeine, the most widely consumed psychostimulant globally, is present in various thermogenic and gym supplements. Low and moderate doses of caffeine antagonize adenosine receptors and have been linked to improved memory and pain relief. We have previously demonstrated that consuming caffeine prevents the risk-taking behavior triggered by nandrolone. In this study, we aimed to investigate the long-term effects of ND and caffeine, either alone or in combination, on passive avoidance memory and nociception. We used the step-down and hot-plate tasks in male and female Lister Hooded rats. Our results confirmed the antinociceptive effect of caffeine and indicated that chronic administration of the ND-caffeine association promotes the evocation of aversive memory in female rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reacción de Prevención / Cafeína / Nocicepción / Nandrolona Decanoato / Memoria Límite: Animals Idioma: En Revista: Brain Res Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reacción de Prevención / Cafeína / Nocicepción / Nandrolona Decanoato / Memoria Límite: Animals Idioma: En Revista: Brain Res Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos