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Study of the effect of ACYP2 single nucleotide polymorphisms rs843711 and rs843706 in Egyptian patients with hepatocellular carcinoma.
Salem, Ramy M; Elshamy, Shahinaz A; Hamed, Amira I; Fathi, Marium E A; Ghanem, Dina T.
Afiliación
  • Salem RM; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Elshamy SA; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Hamed AI; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Fathi MEA; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Ghanem DT; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Egypt J Immunol ; 31(2): 122-129, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38615271
ABSTRACT
Hepatocellular carcinoma (HCC) is a multifactorial disease with both genetic and environmental factors contributing to its pathogenesis. ACYP2 is a gene that is related to cell differentiation, apoptosis and prevention of malignant tumors. The ACYP2 gene also affects telomere length. The aim of this study was to evaluate the association between ACYP2 single nucleotide polymorphisms (SNPs) (rs843711), and (rs843706) and incidence of HCC in Egyptian HCC patients. The study included 30 patients with HCC and 30 normal controls. Detection of ACYP2 gene SNPs rs843711, and rs843706 in all study participants was done using real time polymerase chain reaction (RT-PCR). The results showed that all participants including HCC patients and controls carried the heterozygous CA (100%) of the rs843706 SNP (p> 0.05). As for the rs843711, 3.3% of HCC patients had the homozygous TT genotype, 46.7% had the heterozygous CT genotype and 50% had the wild CC genotype, while in the control group, 60% had the heterozygous CT genotype and 40% had the wild CC genotype with no significant difference between both groups (p>0.05). We concluded that there was no association between SNPs ACYP2 rs843706 and rs843711 and occurrence of HCC.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Acilfosfatasa / Neoplasias Hepáticas Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Egypt J Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Egipto
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Acilfosfatasa / Neoplasias Hepáticas Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Egypt J Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Egipto