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Association between estrogen receptor alpha and aryl hydrocarbon receptor gene polymorphisms in the prognosis of breast cancer in Egypt.
Aboelroos, Sara A; Eltamany, Elsayed H M; Mohamed, Faten A M; Suliman, Marwa A.
Afiliación
  • Aboelroos SA; Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
  • Eltamany EHM; Department of Organic Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt.
  • Mohamed FAM; Department of Biochemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt.
  • Suliman MA; Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Egypt J Immunol ; 31(2): 87-92, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38615265
ABSTRACT
Breast cancer is the most malignant tumor among women in the world. Single nucleotide polymorphisms (SNPs) might better predict breast cancer prognosis. PvuII (T/C substitution), XbaI (A/G substitution), and aryl hydrocarbon (AhR) (G/A substitution) were evaluated as possible genetic prognostic factors for breast cancer. The aim of the current study was to assess the relation between PvuII (rs2234693), XbaI (rs9340799), and aryl hydrocarbon receptor gene polymorphisms AhR (rs2066853) in breast cancer prognosis. This was a case-control study that included 120 breast cancer patients classified into two groups. The first group included 60 patients with good prognostic factors, and the second group included 60 patients with poor prognostic factors. Blood samples were taken from all study participants to perform the genotyping assay. We found that positive genotypes of PvuII, XbaI, and AhR polymorphisms were strongly associated with better prognostic factors for breast cancer patients, while negative genotypes of PvuII and XbaI were more and significantly prevalent in poor prognostic breast cancer patients. We conclude that PvuII T/C, XbaI G/A, and AhR G/A alleles may be prognostic for breast cancer progression.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Receptores de Hidrocarburo de Aril / Receptor alfa de Estrógeno Límite: Female / Humans País/Región como asunto: Africa Idioma: En Revista: Egypt J Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Egipto
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Receptores de Hidrocarburo de Aril / Receptor alfa de Estrógeno Límite: Female / Humans País/Región como asunto: Africa Idioma: En Revista: Egypt J Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Egipto