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Biomarkers for phenotype-endotype relationship in atopic dermatitis: a critical review.
Park, Chang Ook; Kim, Su Min; Lee, Kwang Hoon; Bieber, Thomas.
Afiliación
  • Park CO; Department of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: copark@yuhs.ac.
  • Kim SM; Department of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
  • Lee KH; Department of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
  • Bieber T; Christine Kühne-Center of Allergy Research and Education, Medicine Campus, Davos, Switzerland.
EBioMedicine ; 103: 105121, 2024 May.
Article en En | MEDLINE | ID: mdl-38614010
ABSTRACT
Atopic dermatitis (AD) is the most common form of chronic skin inflammation with diverse clinical variants. Historically, various AD phenotypes have been grouped together without considering their heterogeneity. This approach has resulted in a lack of phenotype- and endotype-adapted therapeutic strategies. Comprehensive insights into AD pathogenesis have enabled precise medicinal approach for AD. These efforts aimed to redefine the endophenotype of AD and develop various biomarkers for diverse purposes. Among these endeavours, efforts are underway to elucidate the mechanisms (and related biomarkers) that lead to the emergence and progression of atopic diseases originating from AD (e.g., atopic march). This review focuses on diverse AD phenotypes and calls for a definition of endophenotypes. While awaiting scientific validation, these biomarkers ensure predicting disease onset and trajectory and tailoring therapeutic strategies for the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenotipo / Biomarcadores / Dermatitis Atópica Límite: Animals / Humans Idioma: En Revista: EBioMedicine Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenotipo / Biomarcadores / Dermatitis Atópica Límite: Animals / Humans Idioma: En Revista: EBioMedicine Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos