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Nephroprotective effects of coriander (Coriandrum sativum) leaves aqueous extracts in aristolochic acid-intoxicated zebrafish embryos.
Tsai, Jen-Ning; Wang, Yun-Hsin; Lin, Po-Ju; Chang, Chiung-Fang; Sun, Chiao-Yin; Chen, Yau-Hung.
Afiliación
  • Tsai JN; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.
  • Wang YH; Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan.
  • Lin PJ; Department of Chemistry, Tamkang University, New Taipei City, Taiwan.
  • Chang CF; Division of Basic Research, Sun Yat-Sen Cancer Center, Koo Foundation, Taipei, Taiwan.
  • Sun CY; Department of Chemistry, Tamkang University, New Taipei City, Taiwan.
  • Chen YH; Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.
Environ Toxicol ; 39(7): 4014-4021, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38613516
ABSTRACT
Coriander is a notable medicinal plant known for its diverse properties, including anti-inflammatory, antioxidant, anticancer, analgesic, and anti-diabetic effects. Despite its recognized health benefits, research on its nephroprotective properties is limited. This study aimed to investigate the potential nephroprotective properties of an aqueous extract derived from coriander leaves using an aristolochic acid-intoxicated zebrafish model. To assess kidney abnormalities induced by aristolochic acid (AA), we utilized the transgenic line Tg(wt1begfp), which expresses green fluorescent protein (GFP) in the kidney. Our previous report indicated that AA exposure leads to acute renal failure in zebrafish characterized by kidney malformation and impaired renal function. However, pretreatment of coriander extract (CE) can mitigate kidney malformations induced by AA. In addition, CE pretreatment reduces the accumulation of red blood cells in the glomerular region. To verify the nephroprotective effects of CE, we analyzed renal function by measuring the glomerular filtration rate in zebrafish embryos. Results indicate that CE partially mitigates renal function impairment caused by AA exposure, suggesting its potential to attenuate AA-induced renal failure. Mechanistically, pretreatment with CE reduces the expression of proinflammatory and proapoptotic genes induced by AA. This suggests that CE likely alleviates acute renal failure by reducing inflammation and apoptosis. As a result, we regard zebrafish as a valuable model for screening natural compounds that have the potential to alleviate AA-induced nephrotoxicity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Extractos Vegetales / Hojas de la Planta / Coriandrum / Ácidos Aristolóquicos / Embrión no Mamífero / Riñón Límite: Animals Idioma: En Revista: Environ Toxicol Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Extractos Vegetales / Hojas de la Planta / Coriandrum / Ácidos Aristolóquicos / Embrión no Mamífero / Riñón Límite: Animals Idioma: En Revista: Environ Toxicol Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos