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Influence of Various Strontium Formulations (Ranelate, Citrate, and Chloride) on Bone Mineral Density, Morphology, and Microarchitecture: A Comparative Study in an Ovariectomized Female Mouse Model of Osteoporosis.
Tomczyk-Warunek, Agnieszka; Turzanska, Karolina; Posturzynska, Agnieszka; Kowal, Filip; Blicharski, Tomasz; Pano, Inés Torné; Winiarska-Mieczan, Anna; Nikodem, Anna; Dresler, Slawomir; Sowa, Ireneusz; Wójciak, Magdalena; Dobrowolski, Piotr.
Afiliación
  • Tomczyk-Warunek A; Laboratory of Locomotor Systems Research, Department of Rehabilitation and Physiotherapy, Medical University of Lublin, 20-954 Lublin, Poland.
  • Turzanska K; Department of Orthopaedics and Rehabilitation, Medical University of Lublin, 20-954 Lublin, Poland.
  • Posturzynska A; Department of Orthopaedics and Rehabilitation, Medical University of Lublin, 20-954 Lublin, Poland.
  • Kowal F; Department of Orthopaedics and Rehabilitation, Medical University of Lublin, 20-954 Lublin, Poland.
  • Blicharski T; Department of Orthopaedics and Rehabilitation, Medical University of Lublin, 20-954 Lublin, Poland.
  • Pano IT; Department of Orthopaedics and Rehabilitation, Medical University of Lublin, 20-954 Lublin, Poland.
  • Winiarska-Mieczan A; Department of Bromatology and Nutrition Physiology, Institute of Animal Nutrition and Bromatology, University of Life Sciences in Lublin, Akademicka St. 13, 20-950 Lublin, Poland.
  • Nikodem A; Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego, 50-370 Wroclaw, Poland.
  • Dresler S; Department of Analytical Chemistry, Medical University of Lublin, 20-093 Lublin, Poland.
  • Sowa I; Department of Plant Physiology and Biophysics, Institute of Biological Science, Maria Curie-Sklodowska University, 20-033 Lublin, Poland.
  • Wójciak M; Department of Analytical Chemistry, Medical University of Lublin, 20-093 Lublin, Poland.
  • Dobrowolski P; Department of Analytical Chemistry, Medical University of Lublin, 20-093 Lublin, Poland.
Int J Mol Sci ; 25(7)2024 Apr 06.
Article en En | MEDLINE | ID: mdl-38612883
ABSTRACT
Osteoporosis stands out as a prevalent skeletal ailment, prompting exploration into potential treatments, including dietary strontium ion supplements. This study assessed the efficacy of supplementation of three strontium forms-strontium citrate (SrC), strontium ranelate (SrR), and strontium chloride (SrCl)-for enhancing bone structure in 50 female SWISS mice, aged seven weeks. In total, 40 mice underwent ovariectomy, while 10 underwent sham ovariectomy. Ovariectomized (OVX) mice were randomly assigned to the following groups OVX (no supplementation), OVX + SrR, OVX + SrC, and OVX + SrCl, at concentrations equivalent to the molar amount of strontium. After 16 weeks, micro-CT examined trabeculae and cortical bones, and whole-bone strontium content was determined. Results confirm strontium administration increased bone tissue mineral density (TMD) and Sr content, with SrC exhibiting the weakest effect. Femur morphometry showed limited Sr impact, especially in the OVX + SrC group. This research highlights strontium's potential in bone health, emphasizing variations in efficacy among its forms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Estroncio / Tiofenos / Ácido Cítrico Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Estroncio / Tiofenos / Ácido Cítrico Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza