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Inflammasome-Related Genetic Polymorphisms as Severity Biomarkers of COVID-19.
Pulito-Cueto, Verónica; Sebastián Mora-Gil, María; Ferrer-Pargada, Diego; Remuzgo-Martínez, Sara; Genre, Fernanda; Lera-Gómez, Leticia; Alonso-Lecue, Pilar; Batista-Liz, Joao Carlos; Tello-Mena, Sandra; Abascal-Bolado, Beatriz; Izquierdo, Sheila; Ruiz-Cubillán, Juan José; Armiñanzas-Castillo, Carlos; Blanco, Ricardo; González-Gay, Miguel A; López-Mejías, Raquel; Cifrián, José M.
Afiliación
  • Pulito-Cueto V; Immunopathology Group, Marqués de Valdecilla University Hospital-Valdecilla Research Institute (IDIVAL), 39008 Santander, Spain.
  • Sebastián Mora-Gil M; Department of Rheumatology, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
  • Ferrer-Pargada D; Immunopathology Group, Marqués de Valdecilla University Hospital-Valdecilla Research Institute (IDIVAL), 39008 Santander, Spain.
  • Remuzgo-Martínez S; Department of Rheumatology, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
  • Genre F; Department of Pneumology, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
  • Lera-Gómez L; Valdecilla Research Institute (IDIVAL), 39011 Santander, Spain.
  • Alonso-Lecue P; Valdecilla Research Institute (IDIVAL), 39011 Santander, Spain.
  • Batista-Liz JC; Department of Microbiology, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
  • Tello-Mena S; Immunopathology Group, Marqués de Valdecilla University Hospital-Valdecilla Research Institute (IDIVAL), 39008 Santander, Spain.
  • Abascal-Bolado B; Department of Pneumology, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
  • Izquierdo S; Immunopathology Group, Marqués de Valdecilla University Hospital-Valdecilla Research Institute (IDIVAL), 39008 Santander, Spain.
  • Ruiz-Cubillán JJ; Department of Rheumatology, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
  • Armiñanzas-Castillo C; Department of Pneumology, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
  • Blanco R; Department of Pneumology, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
  • González-Gay MA; Department of Pneumology, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
  • López-Mejías R; Department of Pneumology, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
  • Cifrián JM; Department of Infectious Diseases, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
Int J Mol Sci ; 25(7)2024 Mar 27.
Article en En | MEDLINE | ID: mdl-38612539
ABSTRACT
The most critical forms of coronavirus disease 2019 (COVID-19) are associated with excessive activation of the inflammasome. Despite the COVID-19 impact on public health, we still do not fully understand the mechanisms by which the inflammatory response influences disease prognosis. Accordingly, we aimed to elucidate the role of polymorphisms in the key genes of the formation and signaling of the inflammasome as biomarkers of COVID-19 severity. For this purpose, a large and well-defined cohort of 377 COVID-19 patients with mild (n = 72), moderate (n = 84), severe (n = 100), and critical (n = 121) infections were included. A total of 24 polymorphisms located in inflammasome-related genes (NLRP3, NLRC4, NLRP1, CARD8, CASP1, IL1B, IL18, NFKB1, ATG16L1, and MIF) were genotyped in all of the patients and in the 192 healthy controls (HCs) (who were without COVID-19 at the time of and before the study) by RT-qPCR. Our results showed that patients with mild, moderate, severe, and critical COVID-19 presented similar allelic and genotypic distribution in all the variants studied. No statistically significant differences in the haplotypic distribution of NLRP3, NLRC4, NLRP1, CARD8, CASP1, IL1B, and ATG16L1 were observed between COVID-19 patients, who were stratified by disease severity. Each stratified group of patients presented a similar genetic distribution to the HCs. In conclusion, our results suggest that the inflammasome polymorphisms studied are not associated with the worsening of COVID-19.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inflamasomas / COVID-19 Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inflamasomas / COVID-19 Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza