Your browser doesn't support javascript.
loading
Design and fabrication of functionalized curdlan-curcumin delivery system to facilitate the therapeutic effects of curcumin on breast cancer.
Ganie, Showkat Ali; Naik, Rayees Ahmad; Dar, Ovas Ahmad; Rather, Luqman Jameel; Assiri, Mohammed A; Li, Qing.
Afiliación
  • Ganie SA; State Key Laboratory of Resource Insects, Chongqing Engineering Research Centre for Biomaterial Fiber and Modern Textile, College of Sericulture, Textile and Biomass Science, Southwest University, 400715 Chongqing, PR China. Electronic address: showkat443@swu.edu.cn.
  • Naik RA; Department of Zoology, Dr. Harisingh Gour Vishwavidyalaya Sagar, Madhya Pradesh 470003, India.
  • Dar OA; College of Pharmaceutical Sciences, Southwest University, 400715 Chongqing, PR China. Electronic address: ovasdar@swu.edu.cn.
  • Rather LJ; State Key Laboratory of Resource Insects, Chongqing Engineering Research Centre for Biomaterial Fiber and Modern Textile, College of Sericulture, Textile and Biomass Science, Southwest University, 400715 Chongqing, PR China.
  • Assiri MA; Department of Chemistry, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia. Electronic address: maassiri@kku.edu.sa.
  • Li Q; State Key Laboratory of Resource Insects, Chongqing Engineering Research Centre for Biomaterial Fiber and Modern Textile, College of Sericulture, Textile and Biomass Science, Southwest University, 400715 Chongqing, PR China. Electronic address: qingli@swu.edu.cn.
Int J Biol Macromol ; 267(Pt 1): 131388, 2024 May.
Article en En | MEDLINE | ID: mdl-38608982
ABSTRACT
We developed a facile method for the fabrication of a biodegradable delivery system composed of two blocks curdlan and curcumin. This was achieved by chemical functionalization of curdlan through tosylation, amination followed by complexation with curcumin. A comprehensive evaluation of structural characterization and component stability showed that cur-cum complex exhibited better anticancer properties with enhanced thermal properties. The cur-cum complex shows pH sensitive sustained release behaviour with higher release at acidic pH and kinetic data of drug release follows the Korsmeyer-Peppas model. The cur-cum complex has ability to block the proliferation of the MCF-7 cell line as revealed by MTT assay which showed increased toxicity of cur-cum complex against these cell lines. The results obtained from western blot analysis demonstrated that the co-administration of cur and cum effectively induced apoptosis in MCF-7 cells. This effect was observed by a considerable upregulation of the Bcl-2/Bax ratio, a decline in mRNA expression of LDHA, level of lactate and LDH activity. The results clearly depict the role of functionalized curdlan as efficient carrier for curcumin delivery with prolonged, sustained release and enhanced bioavailability, thereby improving the overall anticancer activity.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Apoptosis / Curcumina / Beta-Glucanos / Liberación de Fármacos Límite: Female / Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Apoptosis / Curcumina / Beta-Glucanos / Liberación de Fármacos Límite: Female / Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos