Your browser doesn't support javascript.
loading
Two recurrent types of IGH::5' BCL2 breakpoints representing cytogenetic ins(14;18)(q32;q21q21) and t(14;18)(q32;q21), mediated by the VDJ and class switch recombination processes, respectively.
Maekawa, Fumiyo; Hayashida, Masahiko; Takeoka, Kayo; Fukutsuka, Katsuhiro; Nakagawa, Miho; Akasaka, Takashi; Sakamoto, Shinichi; Sumiyoshi, Shinji; Kobashi, Yoichiro; Ohno, Hitoshi.
Afiliación
  • Maekawa F; Tenri Institute of Medical Research, Tenri Hospital, Tenri, Nara, Japan.
  • Hayashida M; Tenri Institute of Medical Research, Tenri Hospital, Tenri, Nara, Japan.
  • Takeoka K; Tenri Institute of Medical Research, Tenri Hospital, Tenri, Nara, Japan.
  • Fukutsuka K; Tenri Institute of Medical Research, Tenri Hospital, Tenri, Nara, Japan.
  • Nakagawa M; Tenri Institute of Medical Research, Tenri Hospital, Tenri, Nara, Japan.
  • Akasaka T; Department of Hematology, Tenri Hospital, Tenri, Nara, Japan.
  • Sakamoto S; Department of Diagnostic Pathology, Tenri Hospital, Tenri, Nara, Japan.
  • Sumiyoshi S; Department of Diagnostic Pathology, Tenri Hospital, Tenri, Nara, Japan.
  • Kobashi Y; Department of Diagnostic Pathology, Tenri Hospital, Tenri, Nara, Japan.
  • Ohno H; Tenri Institute of Medical Research, Tenri Hospital, Tenri, Nara, Japan.
Leuk Lymphoma ; 65(8): 1100-1109, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38608254
ABSTRACT
We describe two types of IGHBCL2 breakpoints involving the 5' region of BCL2 (5' BCL2). One was ins(14;18)(q32;q21q21) observed in 2 follicular lymphoma (FL) cases, in which IGH was cleaved at 3' of IGHD and 5' of IGHJ and BCL2 was cleaved at 5' BCL2 and downstream regions, and a 281- or 201-kilobase pair fragment containing the BCL2 protein-coding sequences was invertedly inserted into IGH. In another type observed in 2 FL and 2 chronic lymphocytic leukemia (CLL) cases, breakage and reunion occurred within the switch region associated with IGHM (Sµ) and 5' BCL2, creating IGH Sµ5' BCL2 fusion sequences on der(18)t(14;18)(q32;q21). The former is considered to be mediated by VDJ-recombination, while the latter by the class switch recombination process. There were no particular features in FL or CLL cases with IGH5' BCL2 breakpoints compared with those with t(14;18)(q32;q21)/IGHBCL2 involving the 3' breakpoint cluster regions.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Translocación Genética / Cromosomas Humanos Par 14 / Cromosomas Humanos Par 18 / Cadenas Pesadas de Inmunoglobulina / Proteínas Proto-Oncogénicas c-bcl-2 / Puntos de Rotura del Cromosoma Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Translocación Genética / Cromosomas Humanos Par 14 / Cromosomas Humanos Par 18 / Cadenas Pesadas de Inmunoglobulina / Proteínas Proto-Oncogénicas c-bcl-2 / Puntos de Rotura del Cromosoma Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos