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Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma.
Ren, Qun-Li; Li, Xiao-Lan; Tian, Tian; Li, Shuang; Shi, Rong-Yi; Wang, Qian; Zhu, Yuan; Wang, Miao; Hu, Huan; Liu, Jian-Guo.
Afiliación
  • Ren QL; School of Stomatology, Zunyi Medical University, Zunyi, Guizhou Province, 563000, China.
  • Li XL; Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution, Zunyi Medical University, Zunyi, Guizhou Province, 563000, China.
  • Tian T; School of Stomatology, Zunyi Medical University, Zunyi, Guizhou Province, 563000, China.
  • Li S; Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution, Zunyi Medical University, Zunyi, Guizhou Province, 563000, China.
  • Shi RY; School of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou Province, 563000, China.
  • Wang Q; School of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou Province, 563000, China.
  • Zhu Y; School of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou Province, 563000, China.
  • Wang M; School of Stomatology, Zunyi Medical University, Zunyi, Guizhou Province, 563000, China.
  • Hu H; Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution, Zunyi Medical University, Zunyi, Guizhou Province, 563000, China.
  • Liu JG; School of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou Province, 563000, China.
Chin J Integr Med ; 30(9): 852-864, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38607612
ABSTRACT
Oral squamous cell carcinoma (OSCC) is the most common malignant cancer of the head and neck, with high morbidity and mortality, ranking as the sixth most common cancer in the world. The treatment of OSCC is mainly radiotherapy, chemotherapy and surgery, however, the prognosis of patients is still poor and the recurrence rate is high. This paper reviews the range of effects of natural medicinal plant active ingredients (NMPAIs) on OSCC cancer, including the types of NMPAIs, anti-cancer mechanisms, involved signaling pathways, and clinical trials. The NMPAIs include terpenoids, phenols, flavonoids, glycosides, alkaloids, coumarins, and volatile oils. These active ingredients inhibit proliferation, induce apoptosis and autophagy, inhibit migration and invasion of OSCC cells, and regulate cancer immunity to exert anti-cancer effects. The mechanism involves signaling pathways such as mitogen-activated protein kinase, phosphatidylinositol 3 kinase/protein kinase B, nuclear factor kappa B, miR-22/WNT1/ß-catenin and Nrf2/Keap1. Clinically, NMPAIs can inhibit the growth of OSCC, and the combined drug is more effective. Natural medicinal plants are promising candidates for the treatment of OSCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Neoplasias de la Boca / Carcinoma de Células Escamosas Límite: Humans Idioma: En Revista: Chin J Integr Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Neoplasias de la Boca / Carcinoma de Células Escamosas Límite: Humans Idioma: En Revista: Chin J Integr Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China