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Cardiovascular Risk in Patients With Treated Isolated Diastolic Hypertension and Isolated Low Diastolic Blood Pressure.
Chang, Wei-Lun; Chen, Ying-Fan; Lee, Yu-Hsuan; Shiu, Ming-Neng; Chang, Po-Yin; Guo, Chao-Yu; Huang, Chi-Jung; Chiang, Chern-En; Chen, Chen-Huan; Chuang, Shao-Yuan; Cheng, Hao-Min.
Afiliación
  • Chang WL; Division of Faculty Development Taipei Veterans General Hospital Taipei Taiwan.
  • Chen YF; Department of Internal Medicine Taipei Veterans General Hospital Taipei Taiwan.
  • Lee YH; Division of Faculty Development Taipei Veterans General Hospital Taipei Taiwan.
  • Shiu MN; Department of Pharmacy, College of Pharmaceutical Sciences National Yang Ming Chiao Tung University Taipei Taiwan.
  • Chang PY; Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration Silver Spring MD USA.
  • Guo CY; Division of Biostatistics and Data science Institute of Public Health, College of Medicine, National Yang Ming Chiao Tung University Taipei Taiwan.
  • Huang CJ; Center for Evidence-based Medicine Taipei Veterans General Hospital Taipei Taiwan.
  • Chiang CE; School of Medicine, College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan.
  • Chen CH; Division of Cardiology, Department of Medicine Taipei Veterans General Hospital Taipei Taiwan.
  • Chuang SY; School of Medicine, College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan.
  • Cheng HM; Division of Cardiology, Department of Medicine Taipei Veterans General Hospital Taipei Taiwan.
J Am Heart Assoc ; 13(8): e032771, 2024 Apr 16.
Article en En | MEDLINE | ID: mdl-38606761
ABSTRACT

BACKGROUND:

The prognosis of high or markedly low diastolic blood pressure (DBP) with normalized on-treatment systolic blood pressure on major adverse cardiovascular events (MACEs) is uncertain. This study examined whether treated isolated diastolic hypertension (IDH) and treated isolated low DBP (ILDBP) were associated with MACEs in patients with hypertension. METHODS AND

RESULTS:

A total of 7582 patients with on-treatment systolic blood pressure <130 mm Hg from SPRINT (Systolic Blood Pressure Intervention Trial) were categorized on the basis of average DBP <60 mm Hg (n=1031; treated ILDBP), 60 to 79 mm Hg (n=5432), ≥80 mm Hg (n=1119; treated IDH). MACE risk was estimated using Cox proportional-hazards models. Among the SPRINT participants, median age was 67.0 years and 64.9% were men. Over a median follow-up of 3.4 years, 512 patients developed a MACE. The incidence of MACEs was 3.9 cases per 100 person-years for treated ILDBP, 1.9 cases for DBP 60 to 79 mm Hg, and 1.8 cases for treated IDH. Comparing with DBP 60 to 79 mm Hg, treated ILDBP was associated with an 1.32-fold MACE risk (hazard ratio [HR], 1.32, 95% CI, 1.05-1.66), whereas treated IDH was not (HR, 1.18 [95% CI, 0.87-1.59]). There was no effect modification by age, sex, atherosclerotic cardiovascular disease risk, or cardiovascular disease history (all P values for interaction >0.05).

CONCLUSIONS:

In this secondary analysis of SPRINT, among treated patients with normalized systolic blood pressure, excessively low DBP was associated with an increased MACE risk, while treated IDH was not. Further research is required for treated ILDBP management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Hipertensión / Hipotensión Límite: Aged / Female / Humans / Male Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Hipertensión / Hipotensión Límite: Aged / Female / Humans / Male Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido