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Calcification-associated molecular traits and therapeutic strategies in hormone receptor-positive HER2-negative breast cancer.
Li, Yuwei; Xu, Yuzheng; Lin, Caijin; Jin, Xi; Ma, Ding; Shao, Zhiming.
Afiliación
  • Li Y; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
  • Xu Y; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
  • Lin C; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
  • Jin X; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
  • Ma D; Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
  • Shao Z; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Cancer Biol Med ; 21(5)2024 Apr 09.
Article en En | MEDLINE | ID: mdl-38605478
ABSTRACT

OBJECTIVE:

Mammographic calcifications are a common feature of breast cancer, but their molecular characteristics and treatment implications in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer remain unclear.

METHODS:

We retrospectively collected mammography records of an HR+/HER2- breast cancer cohort (n = 316) with matched clinicopathological, genomic, transcriptomic, and metabolomic data. On the basis of mammographic images, we grouped tumors by calcification status into calcification-negative tumors, tumors with probably benign calcifications, tumors with calcification of low-moderate suspicion for maligancy and tumors with calcification of high suspicion for maligancy. We then explored the molecular characteristics associated with each calcification status across multiple dimensions.

RESULTS:

Among the different statuses, tumors with probably benign calcifications exhibited elevated hormone receptor immunohistochemical staining scores, estrogen receptor (ER) pathway activation, lipid metabolism, and sensitivity to endocrine therapy. Tumors with calcifications of high suspicion for malignancy had relatively larger tumor sizes, elevated lymph node metastasis incidence, Ki-67 staining scores, genomic instability, cell cycle pathway activation, and may benefit from cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors.

CONCLUSIONS:

Our research established links between tumor calcifications and molecular features, thus proposing potential precision treatment strategies for HR+/HER2- breast cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Calcinosis / Mamografía / Receptores de Estrógenos / Receptor ErbB-2 Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Cancer Biol Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Calcinosis / Mamografía / Receptores de Estrógenos / Receptor ErbB-2 Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Cancer Biol Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China