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Early life factors and oral microbial signatures define the risk of caries in a Swedish cohort of preschool children.
Eriksen, Carsten; Boustedt, Katarina; Sonne, Si Brask; Dahlgren, Jovanna; Kristiansen, Karsten; Twetman, Svante; Brix, Susanne; Roswall, Josefine.
Afiliación
  • Eriksen C; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.
  • Boustedt K; Department of Paediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Sonne SB; Maxillofacial Unit, Halland Hospital, Halmstad, Sweden.
  • Dahlgren J; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
  • Kristiansen K; Department of Paediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Twetman S; Department of Pediatrics, Queen Silvia Children's Hospital, Västra Götalandsregionen, Gothenburg, Sweden.
  • Brix S; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark. kk@bio.ku.dk.
  • Roswall J; BGI-Shenzhen, Shenzhen, 518083, China. kk@bio.ku.dk.
Sci Rep ; 14(1): 8463, 2024 04 11.
Article en En | MEDLINE | ID: mdl-38605085
ABSTRACT
The oral cavity harbors complex communities comprising bacteria, archaea, fungi, protozoa, and viruses. The oral microbiota is establish at birth and develops further during childhood, with early life factors such as birth mode, feeding practices, and oral hygiene, reported to influence this development and the susceptibility to caries. We here analyzed the oral bacterial composition in saliva of 260 Swedish children at two, three and five years of age using 16S rRNA gene profiling to examine its relation to environmental factors and caries development at five years of age. We were able to assign the salivary bacterial community in each child at each time point to one of seven distinct clusters. We observed an individual dynamic in the development of the oral microbiota related to early life factors, such as being first born, born by C-section, maternal perinatal antibiotics use, with a distinct transition between three and five years of age. Different bacterial signatures depending on age were related to increased caries risk, while Peptococcus consistently linked to reduced risk of caries development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caries Dental / Susceptibilidad a Caries Dentarias Límite: Child, preschool / Humans / Newborn País/Región como asunto: Europa Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caries Dental / Susceptibilidad a Caries Dentarias Límite: Child, preschool / Humans / Newborn País/Región como asunto: Europa Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido