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The effect of low dose intra-articular S(+) ketamine on osteoarthritis in rats: an experimental study.
Neto, Eugênio Dos Santos; Pedro, Pedro Paulo de Alcantara; Cartágenes, Maria do Socorro de Sousa; Neto, José Osvaldo Barbosa; Garcia, João Batista Santos.
Afiliación
  • Neto EDS; Universidade de Brasília, Brasília, DF, Brazil.
  • Pedro PPA; Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Cartágenes MDSS; Universidade Federal do Maranhão, Departamento de Ciências Fisiológicas; Universidade Federal do Maranhão, Laboratório Experimental para Estudo da Dor, São Luiz, MA, Brazil; Faculdade de Medicina da Universidade Ceuma, São Luiz, MA, Brazil.
  • Neto JOB; Universidade Federal do Maranhão, Laboratório Experimental para Estudo da Dor, São Luiz, MA, Brazil; Faculdade de Medicina da Universidade Ceuma, São Luiz, MA, Brazil. Electronic address: jose.barbosa@ceuma.br.
  • Garcia JBS; Universidade Federal do Maranhão, Laboratório Experimental para Estudo da Dor, São Luiz, MA, Brazil; Universidade Federal do Maranhão, Departamento de Anestesiologia, Dor e Paliativos, São Luiz, MA, Brazil.
Braz J Anesthesiol ; 74(3): 844502, 2024.
Article en En | MEDLINE | ID: mdl-38604407
ABSTRACT

BACKGROUND:

This study aimed to investigate the analgesic impact of S(+)-ketamine on pain behavior and synovial inflammation in an osteoarthritis (OA) model.

METHODS:

Animals were grouped as follows OA-Saline (n = 24) and OA-Ketamine (n = 24), OA induced via intra-articular sodium monoiodoacetate (MIA); a Non-OA group (n = 24) served as the control. On the 7th day post OA induction, animals received either saline or S(+)-ketamine (0.5 mg.kg-1). Behavioral and histopathological assessments were conducted up to day 28.

RESULTS:

S(+)-ketamine reduced allodynia from day 7 to 28 and hyperalgesia from day 10 to 28. It notably alleviated weight distribution deficits from day 10 until the end of the study. Significant walking improvement was observed on day 14 in S(+)-ketamine-treated rats. Starting on day 14, OA groups showed grip force decline, which was countered by S(+)-ketamine on day 21. However, S(+)-ketamine did not diminish synovial inflammation.

CONCLUSION:

Low Intra-articular (IA) doses of S(+)-ketamine reduced MIA-induced OA pain but did not reverse synovial histopathological changes. IRB APPROVAL NUMBER 23115 012030/2009-05.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoartritis / Ketamina Límite: Animals Idioma: En Revista: Braz J Anesthesiol Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoartritis / Ketamina Límite: Animals Idioma: En Revista: Braz J Anesthesiol Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil