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Unveiling the hidden effects of hypoxia: Pituitary damage and hormonal imbalance in fat greenling (Hexagrammos otakii).
Wang, Wei; Zhan, Yu; Gao, Dongxu; Lu, Fengzhi; Peng, Lei; Chen, Yan; Han, Jian; Xue, Zhuang.
Afiliación
  • Wang W; Key Laboratory of Applied Biology and Aquaculture of Fish in Northern Liaoning Province, Dalian Ocean University, Dalian 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China.
  • Zhan Y; Key Laboratory of Applied Biology and Aquaculture of Fish in Northern Liaoning Province, Dalian Ocean University, Dalian 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China.
  • Gao D; Key Laboratory of Applied Biology and Aquaculture of Fish in Northern Liaoning Province, Dalian Ocean University, Dalian 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China.
  • Lu F; Key Laboratory of Applied Biology and Aquaculture of Fish in Northern Liaoning Province, Dalian Ocean University, Dalian 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China.
  • Peng L; Key Laboratory of Applied Biology and Aquaculture of Fish in Northern Liaoning Province, Dalian Ocean University, Dalian 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China.
  • Chen Y; Key Laboratory of Applied Biology and Aquaculture of Fish in Northern Liaoning Province, Dalian Ocean University, Dalian 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China.
  • Han J; Key Laboratory of Applied Biology and Aquaculture of Fish in Northern Liaoning Province, Dalian Ocean University, Dalian 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China. Electronic address: hanjian@dlou.edu.cn.
  • Xue Z; Key Laboratory of Applied Biology and Aquaculture of Fish in Northern Liaoning Province, Dalian Ocean University, Dalian 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China. Electronic address: xg-dzyx@163.com.
Sci Total Environ ; 927: 172381, 2024 Jun 01.
Article en En | MEDLINE | ID: mdl-38604374
ABSTRACT

BACKGROUND:

In fisheries, hypoxia stress is one of the most common environmental stresses that often lead to the death of large numbers of fish and cause significant economic losses. The pituitary, an important endocrine gland, lies below the hypothalamus region of the brain. It plays a crucial part in controlling vital physiological functions in fish, such as growth, reproduction, and responses to stress. However, the detailed mechanisms of how hypoxia affects these physiological processes via the pituitary remain largely unknown.

METHODS:

Fat greenlings (Hexagrammous otakii) were exposed to different dissolved oxygen (DO = 7. 6 mg/L and DO = 2 mg/L) for 24 h. miRNA-mRNA association analysis of H. otakii pituitary after hypoxia stress. Detecting apoptosis in H. otakii pituitary using Tunel and qPCR. Subsequent detection of hormones in H. otakii liver, gonads and serum by ELISA.

RESULTS:

In this study, hypoxia causes immune system disorders and inflammatory responses through the combined analysis of miRNAs and mRNAs. Subsequent verification indicated a significant accumulation of reactive oxygen species (ROS) subsequent to hypoxia treatment. The overproduction of ROS cause oxidative stress and apoptosis in the pituitary, ultimately causing pituitary damage and reduced growth hormone and luteinising hormone release.

CONCLUSIONS:

According to the association study of miRNA-mRNA, apoptosis problems caused by hypoxia stress result in H. otakii pituitary damage. In the meantime, this work clarifies the possible impact of hypoxia-stress on the pituitary cells, as well as on the gonadal development and growth of H. otakii.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipófisis Límite: Animals Idioma: En Revista: Sci Total Environ Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipófisis Límite: Animals Idioma: En Revista: Sci Total Environ Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos