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Magnetic resonance imaging features of complete androgen insensitivity syndrome in comparison to Mayer-Rokitansky-Küster-Hauser syndrome.
Nakamata, Akihiro; Matsuki, Mitsuru; Otake, Yuko; Himoto, Yuki; Kaneko, Yo; Nakaya, Moto; Sudo, Naohiro; Kikuchi, Tomohiro; Watanabe, Yuriko; Kobayashi, Ryoma; Masuoka, Sota; Kunitomo, Naoki; Fujii, Hiroyuki; Hamamoto, Kohei; Mori, Harushi.
Afiliación
  • Nakamata A; Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. msa462u@yahoo.co.jp.
  • Matsuki M; Department of Pediatric Radiology, Jichi Children's Medical Center, Tochigi, Japan.
  • Otake Y; Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
  • Himoto Y; Department of Diagnostic Radiology and Nuclear Medicine, Kyoto University Hospital, Kyoto, Japan.
  • Kaneko Y; Department of Radiology, Gifu University School of Medicine, Gifu, Japan.
  • Nakaya M; Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Sudo N; Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
  • Kikuchi T; Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
  • Watanabe Y; Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
  • Kobayashi R; Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
  • Masuoka S; Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
  • Kunitomo N; Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
  • Fujii H; Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
  • Hamamoto K; Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
  • Mori H; Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
Abdom Radiol (NY) ; 49(9): 3220-3231, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38602521
ABSTRACT

PURPOSE:

Complete androgen insensitivity syndrome (CAIS) and Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) share common clinical features such as female phenotype, vaginal hypoplasia, and primary amenorrhea. Magnetic resonance imaging (MRI) is performed to investigate the cause of primary amenorrhea. However, the MRI features are also similar in both disorders. They are ultimately diagnosed by chromosome testing, but there is a possibility of misdiagnosis if chromosome testing is not performed. This study aimed to identify MRI features that are useful for differentiating CAIS from MRKHS.

METHOD:

This multicenter retrospective study included 12 patients with CAIS and 19 patients with MRKHS. Three radiologists blindly evaluated the following features (1) detection of vagina, (2) detection of nodular and cystic structures in the lateral pelvis; undescended testicles and paratesticular cysts in CAIS and rudimentary uteri and ovaries in MRKHS, (3) their location, (4) number of cysts in the cystic structures, and (5) signal intensity on diffusion-weighted images (DWI) and apparent diffusion coefficient (ADC) values of the nodular structures. Statistical comparisons were performed using Mann-Whitney U and Fisher's exact tests.

RESULTS:

Compared with MRKHS, the CAIS group showed significantly detectable vagina, more ventrally located nodular and cystic structures, fewer cysts within the cystic structures, and nodular structures with higher signal intensity on DWI and lower ADC values.

CONCLUSIONS:

MRI features of detectable vagina, location of nodular and cystic structures, number of cysts within the cystic structures, signal intensity on DWI and ADC values of the nodular structures were useful in differentiating CAIS from MRKHS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anomalías Congénitas / Síndrome de Resistencia Androgénica / Imagen por Resonancia Magnética / Trastornos del Desarrollo Sexual 46, XX / Conductos Paramesonéfricos Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Abdom Radiol (NY) Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anomalías Congénitas / Síndrome de Resistencia Androgénica / Imagen por Resonancia Magnética / Trastornos del Desarrollo Sexual 46, XX / Conductos Paramesonéfricos Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Abdom Radiol (NY) Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos