Your browser doesn't support javascript.
loading
NR5A2 gene affects the overall survival of LUAD patients by regulating the activity of CSCs through SNP pathway by OCLR algorithm and immune score.
Wu, Liusheng; Chen, Xiaofan; Zeng, Qi; Lai, Zelin; Fan, Zhengyang; Ruan, Xin; Li, Xiaoqiang; Yan, Jun.
Afiliación
  • Wu L; School of Medicine, Tsinghua University, Beijing, 100084, China.
  • Chen X; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.
  • Zeng Q; Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, 518036, China.
  • Lai Z; Department of Traditional Chinese Medicine, Affiliated Sanming First Hospital of Fujian Medical University, Sanming, 365000, China.
  • Fan Z; Department of Information Technology, Union College of Fujian Normal University, Fuzhou, 350116, China.
  • Ruan X; Department of Information and Computational Sciences, School of Mathematics, Liaoning Normal University, Liaoning, 116029, China.
  • Li X; Department of Graduate School, Xinjiang Medical University, Urumqi, Xinjiang, 830011, China.
  • Yan J; Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, 518036, China.
Heliyon ; 10(7): e28282, 2024 Apr 15.
Article en En | MEDLINE | ID: mdl-38601554
ABSTRACT

Objective:

Differentially expressed genes (DEGs) in lung adenocarcinoma (LUAD) tumor stem cells were screened, and the biological characteristics of NR5A2 gene were investigated.

Methods:

The expression and prognosis of NR5A2 in human LUAD were predicted and analyzed through bioinformatics analysis from a human cancer database. Gene expression and clinical data of LUAD tumor and normal lung tissues were obtained from The Cancer Genome Atlas (TCGA) database, and DEGs associated with lung cancer tumor stem cells (CSCs) were screened. Univariate and multivariate Cox regression models were used to screen and establish prognostic risk prediction models. The immune function of the patients was scored according to the model, and the relative immune functions of the high- and low-risk groups were compared to determine the difference in survival prognosis between the two groups. In addition, we calculated the index of stemness based on the transcriptome of the samples using one-class linear regression (OCLR).

Results:

Bioinformatics analysis of a clinical cancer database showed that NR5A2 was significantly decreased in human LUAD tissues than in normal lung tissues, and the decrease in NR5A2 gene expression shortened the overall survival and progression-free survival of patients with LUAD.

Conclusion:

The NR5A2 gene may regulate LUAD tumor stem cells through selective splicing mutations, thereby affecting the survival and prognosis of patients with lung cancer, and the NR5A2 gene may regulate CSCs through single nucleotide polymorphism.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido