Your browser doesn't support javascript.
loading
Effectiveness of immunoglobulin replacement therapy in preventing infections in patients with chronic obstructive pulmonary disease: a systematic review.
Kim, Justin J Y; Dennett, Liz; Ospina, Maria B; Hicks, Anne; Vliagoftis, Harissios; Adatia, Adil.
Afiliación
  • Kim JJY; Faculty of Medicine, University of Alberta, Edmonton, AB, Canada.
  • Dennett L; Sperber Health Sciences Library University of Alberta, Edmonton, AB, Canada.
  • Ospina MB; Department of Public Health Sciences, Queen's University, Kingston, ON, Canada.
  • Hicks A; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
  • Vliagoftis H; Alberta Respiratory Centre, University of Alberta, Edmonton, AB, Canada.
  • Adatia A; Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Allergy Asthma Clin Immunol ; 20(1): 30, 2024 Apr 10.
Article en En | MEDLINE | ID: mdl-38600554
ABSTRACT

PURPOSE:

Immunoglobulin replacement therapy is a standard treatment for patients with antibody production deficiencies, which is of interest in patients with chronic obstructive pulmonary disease (COPD). This systematic review, registered with PROSPERO (CRD42021281118), assessed the current literature regarding immunoglobulin replacement therapy on COPD clinical outcomes in patients with low immunoglobulin G (IgG) serum concentrations.

METHODS:

Literature searches conducted from inception to August 23, 2021, in databases including MEDLINE, EMBASE, and CINAHL. Population (sex, age, comorbidities), baseline clinical characteristics (pulmonary function testing results, IgG levels), and outcome (hospitalizations, emergency department visits) were extracted after title/abstract and full text screening. The Cochrane risk of bias assessment form was used for risk of bias assessment of randomized controlled trials and the National Heart, Lung, and Blood Institute (NHLBI) assessment was used for pre and post studies.

RESULTS:

A total of 1381 studies were identified in the preliminary search, and 874 records were screened after duplicates were removed. Screening 77 full texts yielded four studies that were included in the review.

CONCLUSION:

It is unclear whether immune globulin replacement therapy reduces acute exacerbation frequency and severity in COPD. Current evidence suggests that it is worth considering, but better developed protocols for administration of immune globulin supplementation is required for future randomized controlled trials.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Allergy Asthma Clin Immunol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Allergy Asthma Clin Immunol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido