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International guidelines for intratumoral and intranodal injection of NBTXR3 nanoparticles in head and neck cancers.
Liem, Xavier; de Baère, Thierry; Vivar, Omar I; Seiwert, Tanguy Y; Shen, Colette; Pápai, Zsuzsanna; Moreno, Victor; Takácsi-Nagy, Zoltán; Helfferich, Frigyes; Thariat, Juliette; Gooi, Zhen; Yom, Sue S; Bossi, Paolo; Ferris, Robert L; Hackman, Trevor G; Le Tourneau, Christophe; Rodriguez, Joseph; Hoffmann, Caroline.
Afiliación
  • Liem X; Department of Radiotherapy-Brachytherapy Unicancer-Oscar Lambret Regional Cancer Center, Lille, France.
  • de Baère T; Interventional Radiology Unit, Institut Gustave Roussy, Villejuif, France.
  • Vivar OI; Université Paris-Saclay, UFR Médecine Le Kremlin-Bicêtre, Le Kremlin Bicêtre, France.
  • Seiwert TY; Global Medical Affairs Department, Nanobiotix, Paris, France.
  • Shen C; Head and Neck Cancer Center, Johns Hopkins University Medical Center, Baltimore, Maryland, USA.
  • Pápai Z; Department of Radiation Oncology, University of North Carolina (UNC) Medical Center, Chapel Hill, North Carolina, USA.
  • Moreno V; Department of Oncology, Hungarian Defense Forces Military Hospital-Honved Hospital, Budapest, Hungary.
  • Takácsi-Nagy Z; START Madrid-FJD Phase I Clinical Trials Unit, Fundación-Jiménez Díaz University Hospital, Madrid, Spain.
  • Helfferich F; Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary.
  • Thariat J; Department of Otolaryngology, Hungarian Defense Forces Military Hospital-Honved Hospital, Budapest, Hungary.
  • Gooi Z; Radiotherapy and Brachytherapy Service, François Baclesse Center, Caen, France.
  • Yom SS; Department of Surgery-Section of Otolaryngology-Head and Neck Surgery, University of Chicago Medical Center, Chicago, Illinois, USA.
  • Bossi P; Department of Radiation Oncology, University of California San Francisco (UCSF) Medical Center, San Francisco, California, USA.
  • Ferris RL; Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences, Public Health, University of Brescia, Brescia, Italy.
  • Hackman TG; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
  • Le Tourneau C; Department of Otolaryngology-Head and Neck Surgery, University of North Carolina (UNC) Medical Center, Chapel Hill, North Carolina, USA.
  • Rodriguez J; Department of Drug Development and Innovation D3i, Institut Curie, Paris-Saclay University, Paris, France.
  • Hoffmann C; ENT Surgical and Medical Service, Hospital Center of Valenciennes (CHV), Valenciennes, France.
Head Neck ; 46(6): 1253-1262, 2024 06.
Article en En | MEDLINE | ID: mdl-38600434
ABSTRACT

BACKGROUND:

An international multidisciplinary panel of experts aimed to provide consensus guidelines describing the optimal intratumoral and intranodal injection of NBTXR3 hafnium oxide nanoparticles in head and neck squamous cell carcinoma (HNSCC) of the oral cavity, oropharynx, and cervical lymph nodes and to review data concerning safety, feasibility, and procedural aspects of administration.

METHODS:

The Delphi method was used to determine consensus. A 4-member steering committee and a 10-member monitoring committee wrote and revised the guidelines, divided into eight sections. An independent 3-member reading committee reviewed the recommendations.

RESULTS:

After two rounds of voting, strong consensus was obtained on all recommendations. Intratumoral and intranodal injection was deemed feasible. NBTXR3 volume calculation, choice of patients, preparation and injection procedure, potential side effects, post injection, and post treatment follow-up were described in detail.

CONCLUSIONS:

Best practices for the injection of NBTXR3 were defined, thus enabling international standardization of intratumoral nanoparticle injection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inyecciones Intralesiones / Carcinoma de Células Escamosas de Cabeza y Cuello / Neoplasias de Cabeza y Cuello Límite: Female / Humans / Male Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inyecciones Intralesiones / Carcinoma de Células Escamosas de Cabeza y Cuello / Neoplasias de Cabeza y Cuello Límite: Female / Humans / Male Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos