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Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus.
Krustev, Eugene; Hanly, John G; Chin, Ricky; Buhler, Katherine A; Urowitz, Murray B; Gordon, Caroline; Bae, Sang-Cheol; Romero-Diaz, Juanita; Sánchez-Guerrero, Jorge; Bernatsky, Sasha; Wallace, Daniel J; Isenberg, David; Rahman, Anisur; Merrill, Joan T; Fortin, Paul R; Gladman, Dafna D; Bruce, Ian N; Petri, Michelle A; Ginzler, Ellen M; Dooley, Mary Anne; Ramsey-Goldman, Rosalind; Manzi, Susan; Jönsen, Andreas; Alarcón, Graciela S; van Vollenhoven, Ronald F; Aranow, Cynthia; Mackay, Meggan; Ruiz-Irastorza, Guillermo; Lim, Sam; Inanc, Murat; Kalunian, Kenneth C; Jacobsen, Søren; Peschken, Christine A; Kamen, Diane L; Askenase, Anca; Buyon, Jill; Fritzler, Marvin J; Clarke, Ann E; Choi, May Y.
Afiliación
  • Krustev E; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Hanly JG; Division of Rheumatology, Department of Medicine and Department of Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada.
  • Chin R; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Buhler KA; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Urowitz MB; Lupus Program, Centre for Prognosis Studies in The Rheumatic Disease and Krembil Research Institute, Toronto Western Hospital and University of Toronto, Toronto, Ontario, Canada.
  • Gordon C; Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
  • Bae SC; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Hanyang University Institute for Rheumatology and Hanyang Institute of Bioscience and Biotechnology, Seoul, Republic of Korea.
  • Romero-Diaz J; Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Mexico.
  • Sánchez-Guerrero J; Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada.
  • Bernatsky S; Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, Canada.
  • Wallace DJ; Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Isenberg D; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
  • Rahman A; Centre for Rheumatology, Department of Medicine, University College London, London, UK.
  • Merrill JT; Centre for Rheumatology, Department of Medicine, University College London, London, UK.
  • Fortin PR; Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
  • Gladman DD; Division of Rheumatology, CHU de Québec, Universite Laval, Quebec City, Quebec, Canada.
  • Bruce IN; Lupus Program, Centre for Prognosis Studies in The Rheumatic Disease and Krembil Research Institute, Toronto Western Hospital and University of Toronto, Toronto, Ontario, Canada.
  • Petri MA; Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, The University of Manchester and The Kellgren Centre for Rheumatology, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
  • Ginzler EM; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Dooley MA; Medicine, SUNY Downstate Medical Center, New York City, New York, USA.
  • Ramsey-Goldman R; Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Manzi S; Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Jönsen A; Allegheny Health Network, Pittsburgh, Pennsylvania, USA.
  • Alarcón GS; Department of Rheumatology, Lund University Department of Clinical Sciences Lund, Lund, Sweden.
  • van Vollenhoven RF; Department of Medicine, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
  • Aranow C; Department of Rheumatology and Clinical Immunology, University of Amsterdam, Amsterdam, Noord-Holland, The Netherlands.
  • Mackay M; Center for Autoimmune and Musculoskeletal Disease, Northwell Health Feinstein Institutes for Medical Research, Manhasset, New York, USA.
  • Ruiz-Irastorza G; Center for Autoimmune and Musculoskeletal Disease, Northwell Health Feinstein Institutes for Medical Research, Manhasset, New York, USA.
  • Lim S; Autoimmune Diseases Research Unit, Department of Internal Medicine, BioCruces Health Research Institute, Hospital Universitario Cruces, University of the Basque Country, Barakaldo, Spain.
  • Inanc M; Division of Rheumatology, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Kalunian KC; Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Fatih, Turkey.
  • Jacobsen S; University of California San Diego School of Medicine, La Jolla, California, USA.
  • Peschken CA; Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Kamen DL; University of Manitoba, Winnipeg, Manitoba, Canada.
  • Askenase A; Medical University of South Carolina, Charleston, South Carolina, USA.
  • Buyon J; Columbia University Medical Center, New York City, New York, USA.
  • Fritzler MJ; Rheumatology, NYU Langone Health, New York City, New York, USA.
  • Clarke AE; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Choi MY; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Lupus Sci Med ; 11(1)2024 Apr 09.
Article en En | MEDLINE | ID: mdl-38599670
ABSTRACT

BACKGROUND:

Cranial neuropathies (CN) are a rare neuropsychiatric SLE (NPSLE) manifestation. Previous studies reported that antibodies to the kinesin family member 20B (KIF20B) (anti-KIF20B) protein were associated with idiopathic ataxia and CN. We assessed anti-KIF20B as a potential biomarker for NPSLE in an international SLE inception cohort.

METHODS:

Individuals fulfilling the revised 1997 American College of Rheumatology (ACR) SLE classification criteria were enrolled from 31 centres from 1999 to 2011 and followed annually in the Systemic Lupus Erythematosus International Collaborating Clinics inception cohort. Anti-KIF20B testing was performed on baseline (within 15 months of diagnosis or first annual visit) samples using an addressable laser bead immunoassay. Logistic regression (penalised maximum likelihood and adjusting for confounding variables) examined the association between anti-KIF20B and NPSLE manifestations (1999 ACR case definitions), including CN, occurring over the first 5 years of follow-up.

RESULTS:

Of the 1827 enrolled cohort members, baseline serum and 5 years of follow-up data were available on 795 patients who were included in this study 29.8% were anti-KIF20B-positive, 88.7% female, and 52.1% White. The frequency of anti-KIF20B positivity differed only for those with CN (n=10) versus without CN (n=785) (70.0% vs 29.3%; OR 5.2, 95% CI 1.4, 18.5). Compared with patients without CN, patients with CN were more likely to fulfil the ACR haematological (90.0% vs 66.1%; difference 23.9%, 95% CI 5.0%, 42.8%) and ANA (100% vs 95.7%; difference 4.3%, 95% CI 2.9%, 5.8%) criteria. In the multivariate analysis adjusting for age at baseline, female, White race and ethnicity, and ACR haematological and ANA criteria, anti-KIF20B positivity remained associated with CN (OR 5.2, 95% CI 1.4, 19.1).

CONCLUSION:

Anti-KIF20B is a potential biomarker for SLE-related CN. Further studies are needed to examine how autoantibodies against KIF20B, which is variably expressed in a variety of neurological cells, contribute to disease pathogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Cinesinas / Lupus Eritematoso Sistémico Límite: Female / Humans / Male Idioma: En Revista: Lupus Sci Med Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Cinesinas / Lupus Eritematoso Sistémico Límite: Female / Humans / Male Idioma: En Revista: Lupus Sci Med Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido