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Cardiac resident macrophages: The core of cardiac immune homeostasis.
Cai, Wenhui; Lian, Lu; Li, Aolin; Zhang, Qianqian; Li, Mengmeng; Zhang, Junping; Xie, YingYu.
Afiliación
  • Cai W; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300183, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
  • Lian L; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300183, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
  • Li A; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300183, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
  • Zhang Q; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
  • Li M; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
  • Zhang J; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300183, China. Electronic address: tjzhtcm@163.com.
  • Xie Y; College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address: xieyingyunn@163.com.
Cell Signal ; 119: 111169, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38599440
ABSTRACT
Cardiac resident macrophages (CRMs) are essential in maintaining the balance of the immune homeostasis in the heart. One of the main factors in the progression of cardiovascular diseases, such as myocarditis, myocardial infarction(MI), and heart failure(HF), is the imbalance in the regulatory mechanisms of CRMs. Recent studies have reported novel heterogeneity and spatiotemporal complexity of CRMs, and their role in maintaining cardiac immune homeostasis and treating cardiovascular diseases. In this review, we focus on the functions of CRMs, including immune surveillance, immune phagocytosis, and immune metabolism, and explore the impact of CRM's homeostasis imbalance on cardiac injury and cardiac repair. We also discuss the therapeutic approaches linked to CRMs. The immunomodulatory strategies targeting CRMs may be a therapeutic approach for the treatment of cardiovascular disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Homeostasis / Macrófagos Límite: Animals / Humans Idioma: En Revista: Cell Signal Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Homeostasis / Macrófagos Límite: Animals / Humans Idioma: En Revista: Cell Signal Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido