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A minimalist cancer cell membrane-shielded biomimetic nanoparticle for nasopharyngeal carcinoma active-targeting therapy.
Sun, Shuo; Han, Rongrong; Sun, Yanju; Chen, Wenqiang; Zhao, Limin; Guan, Xiuwen; Zhang, Weifen.
Afiliación
  • Sun S; School of Clinical Medicine, Shandong Second Medical University, Weifang 261053, China.
  • Han R; Department of Otolaryngology, Weifang People's Hospital, Weifang 261000, China.
  • Sun Y; College of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
  • Chen W; College of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
  • Zhao L; School of Clinical Medicine, Shandong Second Medical University, Weifang 261053, China.
  • Guan X; College of Pharmacy, Shandong Second Medical University, Weifang 261053, China. Electronic address: gxw2603@wfmc.edu.cn.
  • Zhang W; College of Pharmacy, Shandong Second Medical University, Weifang 261053, China. Electronic address: zhangwf@wfmc.edu.cn.
Colloids Surf B Biointerfaces ; 238: 113909, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38599076
ABSTRACT
Nasopharyngeal carcinoma (NPC) is a common head and neck malignancy, which is characterized by high incidence and aggression with poor diagnosis and limited therapeutic opportunity. The innovative strategy for achieving precise NPC active-targeting drug delivery has emerged as a prominent focus in clinical research. Here, a minimalist cancer cell membrane (CCM) shielded biomimetic nanoparticle (NP) was designed for NPC active-targeting therapy. Chemotherapeutant model drug doxorubicin (DOX) was loaded in polyamidoamine (PAMAM) dendrimer. The PAMAM/DOX (PD) NP was further shielded by human CNE-2 NPC CCM. Characterization results verified that the biomimetic PAMAM/DOX@CCM (abbreviated as PDC) NPs had satisfactory physical properties with high DOX-loading and excellent stability. Cell experiments demonstrated that the CNE-2 membrane-cloaked PDC NPs presented powerful cellular uptake in the sourcing cells by homologous targeting and adhesive interaction. Further in vivo results confirmed that this biomimetic nanoplatform had extended circulation and remarkable tumor-targeting capability, and the PDC NPs effectively suppressed the progression of CNE-2 tumors by systemic administration. This CCM-shielded biomimetic NP displayed a minimalist paradigm nanoplatform for precise NPC therapy, and the strategy of CCM-shielded biomimetic drug delivery system (DDS) has great potential for extensive cancer active-targeting therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Doxorrubicina / Membrana Celular / Neoplasias Nasofaríngeas / Materiales Biomiméticos / Nanopartículas / Carcinoma Nasofaríngeo Límite: Animals / Humans Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Doxorrubicina / Membrana Celular / Neoplasias Nasofaríngeas / Materiales Biomiméticos / Nanopartículas / Carcinoma Nasofaríngeo Límite: Animals / Humans Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos