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Fungal microbiota in newborn infants with and without respiratory distress syndrome.
Friaza, Vicente; Rojas, Pilar; de la Horra, Carmen; García, Elisa; Morilla, Rubén; Pavón, Antonio; de Armas, Yaxsier; Vallejo-Vaz, Antonio J; Salsoso, Rocío; Medrano, Francisco J; Calderón, Enrique J.
Afiliación
  • Friaza V; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Madrid, Spain.
  • Rojas P; Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, Seville, Spain.
  • de la Horra C; Neonatology Unit, Virgen del Rocío University Children's Hospital, Seville, Spain.
  • García E; Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, Seville, Spain.
  • Morilla R; Neonatology Unit, Virgen del Rocío University Children's Hospital, Seville, Spain.
  • Pavón A; Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, Seville, Spain.
  • de Armas Y; Departamento de Enfermería, Universidad de Sevilla, Seville, Spain.
  • Vallejo-Vaz AJ; Neonatology Unit, Virgen del Rocío University Children's Hospital, Seville, Spain.
  • Salsoso R; Department of Clinical Microbiology Diagnostic, Hospital Center of Institute of Tropical Medicine "Pedro Kourí", Havana, Cuba.
  • Medrano FJ; Pathology Department, Hospital Center of Institute of Tropical Medicine "Pedro Kourí", Havana, Cuba.
  • Calderón EJ; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Madrid, Spain.
PLoS One ; 19(4): e0302027, 2024.
Article en En | MEDLINE | ID: mdl-38598489
ABSTRACT

BACKGROUND:

Pneumocytis jirovecii infection in preterm newborns has recently been associated with neonatal respiratory distress syndrome and bronchopulmonary dysplasia. Changes in the bacterial microbiota of the airways have also been described in infants with bronchopulmonary dysplasia. However, until now there has been no information on the airway mycobiota in newborns. The purpose of this study was to describe the airway mycobiota in term and preterm newborns and its possible association with respiratory distress syndrome.

METHODS:

Twenty-six matched preterm newborns with and without respiratory distress syndrome were studied, as well as 13 term babies. The identification of the fungal microbiota was carried out using molecular procedures in aspirated nasal samples at birth.

RESULTS:

The ascomycota phylum was identified in 89.7% of newborns, while the basidiomycota phylum was found in 33.3%. Cladosporium was the predominant genus in both term and preterm infants 38.4% vs. 73% without statistical differences. Candida sake and Pneumocystis jirovecii were only found in preterm infants, suggesting a potential relationship with the risk of prematurity.

CONCLUSIONS:

This is the first report to describe the fungal microbiota of the airways in term and preterm infants with and without respiratory distress syndrome. Although no differences have been observed, the number of cases analyzed could be small to obtain conclusive results, and more studies are needed to understand the role of the fungal microbiota of the airways in neonatal respiratory pathology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Dificultad Respiratoria del Recién Nacido / Displasia Broncopulmonar / Pneumocystis carinii / Micobioma Límite: Humans / Infant / Newborn Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Dificultad Respiratoria del Recién Nacido / Displasia Broncopulmonar / Pneumocystis carinii / Micobioma Límite: Humans / Infant / Newborn Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos