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[Biological mechanisms of Oxalis corniculata regulating human prostate cancer PC-3 cells: An investigation based on the NF-κB pathway].
Zhang, Guo-Wei; Zhan, Ming-Wei; Zhan, Xu-Xin; Yu, Yi; Liu, Peng-Fei; Wang, Lei; Wu, Hao; He, Can-Qin; Lou, Qiang; Shang, Xue-Jun.
Afiliación
  • Zhang GW; Department of Urology, Suqian First Hospital, Suqian, Jiangsu 223800, China.
  • Zhan MW; Department of Urology, Jinling Hospital Affiliated to Nanjing University School of Medicine / General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China.
  • Zhan XX; Center of Reproductive Medicine, Xi'an Peoples' Hospital / Xi'an Fourth Hospital, Xi'an, Shaanxi 710004, China.
  • Yu Y; The First Affiliated Hospital Of Ningbo University Ningbo, Zhejiang 315000； 5.Southeast University School of Medicine, Nanjing, Jiangsu 210009, China.
  • Liu PF; Department of Urology, Jinling Hospital Affiliated to Nanjing University School of Medicine / General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China.
  • Wang L; Southeast University School of Medicine, Nanjing, Jiangsu 210009, China; 6.Department of Urology, People's Hospital of Longhua District, Shenzhen, Guangdong 518000, China.
  • Wu H; Department of Urology, People's Hospital of Longhua District, Shenzhen, Guangdong 518000, China.
  • He CQ; Department of Urology, Jinling Hospital Affiliated to Nanjing University School of Medicine / General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China.
  • Lou Q; Department of Urology, The Second Affiliated Hospital of Guizhou University of Chinese Medicine, Guiyang, Guizhou 550001, China.
  • Shang XJ; Department of Urology, Jinling Hospital Affiliated to Nanjing University School of Medicine / General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China.
Zhonghua Nan Ke Xue ; 29(3): 202-209, 2023 Mar.
Article en Zh | MEDLINE | ID: mdl-38597700
ABSTRACT

OBJECTIVE:

To investigate the biological mechanisms underlying the effect of the Chinese herbal medicine Oxalis corniculata on human prostate cancer PC-3 cells.

METHODS:

Through in vitro experiment, we treated human prostate cancer PC-3 cells with different concentrations of Oxalis corniculata, assessed the viability of the cells by MTT assay, examined their apoptosis by flow cytometry, evaluated their migration and invasiveness by Transwell assay, and determined the expressions of the proteins p65, p-p65, IκBα and p-IκBα in the NF-κB pathway using protein imprinting technology.

RESULTS:

Compared with the blank control, Oxalis corniculata significantly inhibited the proliferation and induced the apoptosis of the PC-3 cells (P< 0.05), suppressed their migration and invasiveness in a dose-dependent manner (P< 0.05), and upregulated the expression of IκBα and downregulated those of p-p65 and p-IκBα in the NF-κB pathway (P< 0.05).

CONCLUSION:

Oxalis corniculata can inhibit the proliferation, migration and invasiveness and induce the apoptosis of human prostate cancer PC cells, which may be attributed to its abilities of inhibiting the expressions of p-p65 and p-IκBα and regulating the activity of the NF-κB pathway.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Oxalidaceae Límite: Humans / Male Idioma: Zh Revista: Zhonghua Nan Ke Xue Asunto de la revista: MEDICINA REPRODUTIVA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Oxalidaceae Límite: Humans / Male Idioma: Zh Revista: Zhonghua Nan Ke Xue Asunto de la revista: MEDICINA REPRODUTIVA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: China