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Systemic benefits of periodontal therapy in patients with obesity and periodontitis: a systematic review.
Menezes, Cláudia Callegaro de; Barbirato, Davi da Silva; Fogacci, Mariana Fampa; Marañón-Vásquez, Guido Artemio; Carneiro, João Régis Ivar; Maia, Lucianne Copple; Barros, Maria Cynésia Medeiros de.
Afiliación
  • Menezes CC; Universidade Federal do Rio de Janeiro - UFRJ, Dental School, Division of Periodontics, Rio de Janeiro, RJ, Brazil.
  • Barbirato DDS; Universidade Federal do Rio de Janeiro - UFRJ, Dental School, Division of Periodontics, Rio de Janeiro, RJ, Brazil.
  • Fogacci MF; Universidade Federal de Pernambuco - UFPE, Department of Clinical and Preventive Dentistry, Recife, PE, Brazil.
  • Marañón-Vásquez GA; Universidade Federal do Rio de Janeiro - UFRJ, Department of Pediatric Dentistry, Rio de Janeiro, RJ, Brazil.
  • Carneiro JRI; Universidade Federal do Rio de Janeiro - UFRJ, Clementino Fraga Filho Hospital University, Department of Nutrology/Bariatric Surgery, Rio de Janeiro, RJ, Brazil.
  • Maia LC; Universidade Federal do Rio de Janeiro - UFRJ, Department of Pediatric Dentistry and Orthodontics, Rio de Janeiro, RJ, Brazil.
  • Barros MCM; Universidade Federal do Rio de Janeiro - UFRJ, Dental School, Division of Periodontics, Rio de Janeiro, RJ, Brazil.
Braz Oral Res ; 38: e031, 2024.
Article en En | MEDLINE | ID: mdl-38597549
ABSTRACT
This systematic review aimed to answer the focused question "What are the benefits of subgingival periodontal therapy on blood hematological and biochemical index, biomarkers of inflammation and oxidative stress, quality of life, and periodontal pathogen counts in patients with obesity and periodontitis?". A systematic literature search was performed in six databases PubMed, Embase, LILACS, Web of Science, Cochrane and SCOPUS and other sources, and a manual search was conducted as well. Inclusion criteria were randomized and non-randomized clinical trials, and before-and-after studies on patients with obesity subjected to periodontal therapy. The results were synthesized qualitatively. Risk of bias within studies was assessed using RoB 2 and ROBINS-I tools. The certainty of evidence was evaluated following the GRADE approach. Three randomized controlled trials and 15 before-and-after studies were included. Randomized controlled trials were considered to have a low risk of bias, as compared to before-and-after studies assessed as having low, serious, and critical risks of bias. Non-surgical periodontal therapy plus azithromycin, chlorhexidine, and cetylpyridinium chloride reduced blood pressure and decreased serum levels of HbA1c, hsCRP, IL-1ß, and TNF-α. Salivary resistin level also decreased in patients with obesity and periodontitis after therapy and chlorhexidine mouth rinse. Before-and-after data suggest an improvement in total cholesterol, LDL, triglycerides, insulin resistance, C3, GCF levels of TNF-α, chemerin, vaspin, omentin-1, visfatin, 8-OHdG, and periodontal pathogen counts after therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis / Periodontitis Crónica Límite: Humans Idioma: En Revista: Braz Oral Res Asunto de la revista: ODONTOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis / Periodontitis Crónica Límite: Humans Idioma: En Revista: Braz Oral Res Asunto de la revista: ODONTOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil