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Analysis of drug factors in 5-aminolevulinic acid photodynamic therapy for oral potentially malignant disorder.
Li, Dandan; Yu, Zhujun; Nie, Cheng; Wang, Jianli.
Afiliación
  • Li D; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Pharmacy, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
  • Yu Z; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Pharmacy, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
  • Nie C; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Pharmacy, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
  • Wang J; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Pharmacy, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 41(6): 701-707, 2023 Dec 01.
Article en En, Zh | MEDLINE | ID: mdl-38597036
ABSTRACT

OBJECTIVES:

This study aimed to analyze the influence of drug factors on the efficacy of 5-aminolevulinic acid (ALA) photodynamic therapy for oral potentially malignant disorder to improve clinical efficacy and promote clinical rational drug use.

METHODS:

Literature on the treatment of oral potentially malignant disorder by using ALA photodynamic therapy was collected and analyzed from PubMed, ISI Web of Knowledge database, CNKI, VIP, and Wanfang database.

RESULTS:

A total of 690 cases were collected, with an average complete response rate of 65.94%. The groups treated with 16.8% methyl aminolevulinate cream, local topical, once a week, and pre-activation time of 2-4 hours were better than the other subgroups, with average complete response rates of 100%, 66.91%, 78.28%, and 77.54%, respectively.

CONCLUSIONS:

Drug factors have direct influence on the curative effect. The development of novel oral ALA formulations from the perspective of drug improvement is an important strategy to improve efficacy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Ácido Aminolevulínico Idioma: En / Zh Revista: Hua Xi Kou Qiang Yi Xue Za Zhi Asunto de la revista: ODONTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Ácido Aminolevulínico Idioma: En / Zh Revista: Hua Xi Kou Qiang Yi Xue Za Zhi Asunto de la revista: ODONTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: China