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Telomerase: a nexus between cancer nanotherapy and circadian rhythm.
Ghosh, Pramit Kumar; Rao, Maddila Jagapathi; Putta, Chandra Lekha; Ray, Sandipan; Rengan, Aravind Kumar.
Afiliación
  • Ghosh PK; Department of Biomedical Engineering, Indian Institute of Technology (IIT), Hyderabad, India. aravind@bme.iith.ac.in.
  • Rao MJ; Department of Biomedical Engineering, Indian Institute of Technology (IIT), Hyderabad, India. aravind@bme.iith.ac.in.
  • Putta CL; Department of Biomedical Engineering, Indian Institute of Technology (IIT), Hyderabad, India. aravind@bme.iith.ac.in.
  • Ray S; Department of Biotechnology, Indian Institute of Technology (IIT), Hyderabad, India. sandipan.ray@bt.iith.ac.in.
  • Rengan AK; Department of Biomedical Engineering, Indian Institute of Technology (IIT), Hyderabad, India. aravind@bme.iith.ac.in.
Biomater Sci ; 12(9): 2259-2281, 2024 Apr 30.
Article en En | MEDLINE | ID: mdl-38596876
ABSTRACT
Cancer represents a complex disease category defined by the unregulated proliferation and dissemination of anomalous cells within the human body. According to the GLOBOCAN 2020 report, the year 2020 witnessed the diagnosis of approximately 19.3 million new cases of cancer and 10.0 million individuals succumbed to the disease. A typical cell eventually becomes cancerous because of a long-term buildup of genetic instability and replicative immortality. Telomerase is a crucial regulator of cancer progression as it induces replicative immortality. In cancer cells, telomerase inhibits apoptosis by elongating the length of the telomeric region, which usually protects the genome from shortening. Many nanoparticles are documented as being available for detecting the presence of telomerase, and many were used as delivery systems to transport drugs. Furthermore, telomere homeostasis is regulated by the circadian time-keeping machinery, leading to 24-hour rhythms in telomerase activity and TERT mRNA expression in mammals. This review provides a comprehensive discussion of various kinds of nanoparticles used in telomerase detection, inhibition, and multiple drug-related pathways, as well as enlightens an imperative association between circadian rhythm and telomerase activity from the perspective of nanoparticle-based anticancer therapeutics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ritmo Circadiano / Telomerasa / Nanopartículas / Neoplasias Límite: Animals / Humans Idioma: En Revista: Biomater Sci Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ritmo Circadiano / Telomerasa / Nanopartículas / Neoplasias Límite: Animals / Humans Idioma: En Revista: Biomater Sci Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido