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Aerobic capacity and mitochondrial function in bipolar disorder: a longitudinal study during acute phases and after clinical remission.
Giménez-Palomo, Anna; Guitart-Mampel, Mariona; Roqué, Gemma; Sánchez, Ester; Borràs, Roger; Meseguer, Ana; García-García, Francesc Josep; Tobías, Esther; Valls-Roca, Laura; Anmella, Gerard; Valentí, Marc; Olivier, Luis; de Juan, Oscar; Ochandiano, Iñaki; Andreu, Helena; Radua, Joaquim; Verdolini, Norma; Berk, Michael; Vieta, Eduard; Garrabou, Glòria; Roca, Josep; Alsina-Restoy, Xavier; Pacchiarotti, Isabella.
Afiliación
  • Giménez-Palomo A; Department of Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain.
  • Guitart-Mampel M; Bipolar and Depressive Disorders Unit, Institut d'Investigacions Biomédiques August Pi I Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
  • Roqué G; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
  • Sánchez E; Department of Medicine, School of Medicine and Health Sciences, Institute of Neurosciences (UBNeuro), University of Barcelona (UB), Barcelona, Catalonia, Spain.
  • Borràs R; Inherited Metabolic Diseases and Muscular Disorders Research Lab, Cellex-IDIBAPS, Faculty of Medicine and Health Sciences-University of Barcelona, Internal Medicine Department-Hospital Clinic of Barcelona and Centro de Investigación en Red de Enfermedades Raras (CIBERER), Catalonia, Spain.
  • Meseguer A; Pneumology Department (ICR), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), School of Medicine, University of Barcelona, Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Barcelona, Catalonia, Spain.
  • García-García FJ; Pneumology Department (ICR), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), School of Medicine, University of Barcelona, Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Barcelona, Catalonia, Spain.
  • Tobías E; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
  • Valls-Roca L; Cardiovascular Institute, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Anmella G; Department of Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain.
  • Valentí M; Inherited Metabolic Diseases and Muscular Disorders Research Lab, Cellex-IDIBAPS, Faculty of Medicine and Health Sciences-University of Barcelona, Internal Medicine Department-Hospital Clinic of Barcelona and Centro de Investigación en Red de Enfermedades Raras (CIBERER), Catalonia, Spain.
  • Olivier L; Inherited Metabolic Diseases and Muscular Disorders Research Lab, Cellex-IDIBAPS, Faculty of Medicine and Health Sciences-University of Barcelona, Internal Medicine Department-Hospital Clinic of Barcelona and Centro de Investigación en Red de Enfermedades Raras (CIBERER), Catalonia, Spain.
  • de Juan O; Inherited Metabolic Diseases and Muscular Disorders Research Lab, Cellex-IDIBAPS, Faculty of Medicine and Health Sciences-University of Barcelona, Internal Medicine Department-Hospital Clinic of Barcelona and Centro de Investigación en Red de Enfermedades Raras (CIBERER), Catalonia, Spain.
  • Ochandiano I; Department of Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain.
  • Andreu H; Bipolar and Depressive Disorders Unit, Institut d'Investigacions Biomédiques August Pi I Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
  • Radua J; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
  • Verdolini N; Department of Medicine, School of Medicine and Health Sciences, Institute of Neurosciences (UBNeuro), University of Barcelona (UB), Barcelona, Catalonia, Spain.
  • Berk M; Department of Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain.
  • Vieta E; Bipolar and Depressive Disorders Unit, Institut d'Investigacions Biomédiques August Pi I Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
  • Garrabou G; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
  • Roca J; Department of Medicine, School of Medicine and Health Sciences, Institute of Neurosciences (UBNeuro), University of Barcelona (UB), Barcelona, Catalonia, Spain.
  • Alsina-Restoy X; Department of Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain.
  • Pacchiarotti I; Bipolar and Depressive Disorders Unit, Institut d'Investigacions Biomédiques August Pi I Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
Front Psychiatry ; 15: 1386286, 2024.
Article en En | MEDLINE | ID: mdl-38596629
ABSTRACT

Background:

Aerobic capacity has shown to predict physical and mental health-related quality of life in bipolar disorder (BD). However, the correlation between exercise respiratory capacity and mitochondrial function remains understudied. We aimed to assess longitudinally intra-individual differences in these factors during mood episodes and remission in BD.

Methods:

This study included eight BD patients admitted to an acute psychiatric unit. Incremental cardiopulmonary exercise test (CPET) was conducted during acute episodes (T0), followed by constant work rate cycle ergometry (CWRCE) to evaluate endurance time, oxygen uptake at peak exercise (VO2peak) and at the anaerobic threshold. The second test was repeated during remission (T1). Mitochondrial respiration rates were assessed at T0 and T1 in peripheral blood mononuclear cells.

Results:

Endurance time, VO2peak, and anaerobic threshold oxygen consumption showed no significant variations between T0 and T1. Basal oxygen consumption at T1 tended to inversely correlate with maximal mitochondrial respiratory capacity (r=-0.690, p=0.058), and VO2peak during exercise at T1 inversely correlated with basal and minimum mitochondrial respiration (r=-0.810, p=0.015; r=-0.786, p=0.021, respectively).

Conclusions:

Our preliminary data showed that lower basal oxygen consumption may be linked to greater mitochondrial respiratory capacity, and maximum oxygen uptake during the exercise task was associated with lower basal mitochondrial respiration, suggesting that lower oxygen requirements could be associated with greater mitochondrial capacity. These findings should be replicated in larger samples stratified for manic and depressive states.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Psychiatry Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Psychiatry Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza