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A new Eosin Y-based 'turnon' fluorescent sensor for ratiometric sensing of toxic mercury ion (Hg2+) offering unaided eye detection and its antibacterial activity.
Chakraborty, Arnab; Rajana, Vinod K; Saritha, Cevella; Srivastava, Abhinav; Mandal, Debabrata; Das, Neeladri.
Afiliación
  • Chakraborty A; Department of Chemistry, Indian Institute of Technology Patna, Patna 801106, Bihar, India.
  • Rajana VK; Department of Biotechnology, National Institute of Pharmaceutical Education and Research Hajipur, 844102 Bihar, India.
  • Saritha C; Department of Biotechnology, National Institute of Pharmaceutical Education and Research Hajipur, 844102 Bihar, India.
  • Srivastava A; Department of Chemistry, Indian Institute of Technology Patna, Patna 801106, Bihar, India.
  • Mandal D; Department of Biotechnology, National Institute of Pharmaceutical Education and Research Hajipur, 844102 Bihar, India.
  • Das N; Department of Chemistry, Indian Institute of Technology Patna, Patna 801106, Bihar, India. Electronic address: neeladri@iitp.ac.in.
J Hazard Mater ; 470: 134207, 2024 May 15.
Article en En | MEDLINE | ID: mdl-38593667
ABSTRACT
A unique fluorescent molecule (ND-S) was obtained from Eosin Y in two simple yet high yielding steps (1). ND-S has special metal ion sensing ability, such that it can selectively detect toxic Hg2+ present in very low concentration in aqueous solutions in the presence of other competing metal ions. The host-guest complexation is ratiometric and is associated with significant increase in fluorescence during the process. Isothermal titration calorimetry (ITC) experiments provided thermodynamic parameters related to interaction between ND-S and Hg2+. Using inductively coupled plasma mass spectrometry (ICP-MS), the Hg2+(aq) removal efficiency of ND-S was estimated to be 99.88%. Appreciable limit of detection (LOD = 7.4 nM) was observed. Other competing ions did not interfere with the sensing of Hg2+ by ND-S. The effects of external stimuli (temperature and pH) were studied. Besides, the complex (ND-M), formed by 11 coordination of ND-S and Hg2+ was found to be effective against the survival of Gram-positive bacteria (S. aureus and B. subtilis) with a high selectivity index. Moreover, bacterial cell death mechanism was studied systematically. Overall, we have shown the transformation of a toxic species (Hg2+), extracted from polluted water by a biocompatible sensor (ND-S), into an effective and potent antibacterial agent (ND-M).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Eosina Amarillenta-(YS) / Colorantes Fluorescentes / Mercurio / Antibacterianos Idioma: En Revista: J Hazard Mater Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Eosina Amarillenta-(YS) / Colorantes Fluorescentes / Mercurio / Antibacterianos Idioma: En Revista: J Hazard Mater Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos