Investigation of HLA susceptibility alleles and genotypes with hematological disease among Chinese Han population.
PLoS One
; 19(4): e0281698, 2024.
Article
en En
| MEDLINE
| ID: mdl-38593173
ABSTRACT
Several genes involved in the pathogenesis have been identified, with the human leukocyte antigen (HLA) system playing an essential role. However, the relationship between HLA and a cluster of hematological diseases has received little attention in China. Blood samples (n = 123913) from 43568 patients and 80345 individuals without known pathology were genotyped for HLA class I and II using sequencing-based typing. We discovered that HLA-A*1101, B*4001, C*0102, DQB1*0301, and DRB1*0901 were prevalent in China. Furthermore, three high-frequency alleles (DQB1*0301, DQB1*0602, and DRB1*1501) were found to be hazardous in malignant hematologic diseases when compared to controls. In addition, for benign hematologic disorders, 7 high-frequency risk alleles (A*0101, B*4601, C*0102, DQB1*0303, DQB1*0502, DRB1*0901, and DRB1*1454) and 8 high-frequency susceptible genotypes (A*1101-A*1101, B*4601-B*5801, B*4601-B*4601, C*0102-C*0304, DQB1*0301-DQB1*0502, DQB1*0303-DQB1*0601, DRB1*0901-DRB1*1501, and DRB1*1454-DRB1*1501) were observed. To summarize, our findings indicate the association between HLA alleles/genotypes and a variety of hematological disorders, which is critical for disease surveillance.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos de Histocompatibilidad Clase I
/
Enfermedades Hematológicas
Límite:
Humans
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos