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Association of the key immunological and hemodynamic determinants with cervix ripening in pregnant women.
Shcherbina, Mykola; Potapova, Liliya; Lipko, Oksana; Shcherbina, Irina; Mertsalova, Olga.
Afiliación
  • Shcherbina M; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
  • Potapova L; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
  • Lipko O; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
  • Shcherbina I; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
  • Mertsalova O; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
Wiad Lek ; 77(2): 201-207, 2024.
Article en En | MEDLINE | ID: mdl-38592979
ABSTRACT

OBJECTIVE:

Aim:

To investigate a correlation between cervical ripening, the immunological features and the hemodynamic characteristics of the cervix during the preparation for vaginal labor. PATIENTS AND

METHODS:

Materials and

Methods:

We examined 75 pregnant women at different gestational age. General clinical and immunological studies were conducted in order to check serum concentration of cytokines IL-6, IL-1ß, and TNF-α. Ultrasound and Doppler study were used to determine resistance index and systolic-diastolic ratio of blood flow in the common uterine artery as well as the descending and ascending parts and cervical stromal arteries.

RESULTS:

Results:

Pregnant women with high cervical ripening score had high concentrations of the major proinflammatory cytokines (IL-1ß, IL-6, and TNF-α). Analysis of the of the cervical blood flow indicators of the studied groups showed significant differences in the indices of vascular resistance in the vessels that feed the cervix. Our data showed a significant correlation between the cervix ripening and both the serum levels of the studied cytokines and the level of peripheral vascular resistance indices in the common uterine arteries of the cervix, and the blood flow indices in the cervical stromal vessels.

CONCLUSION:

Conclusions:

Our study shows that the process of preparing the woman's body for labor is associated with immunological adjustment and increased hemodynamics of the cervix. We report that cervical ripening is associated with the immunological components and hemodynamic parameters of the cervix at late-stage pregnancy. Measuring cervix ripening and the accompanied changes in cytokine levels and hemodynamic parameters will form a more accurate assessment of birth preparedness and labor complications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuello del Útero / Mujeres Embarazadas Límite: Female / Humans / Pregnancy Idioma: En Revista: Wiad Lek Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Ucrania Pais de publicación: Polonia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuello del Útero / Mujeres Embarazadas Límite: Female / Humans / Pregnancy Idioma: En Revista: Wiad Lek Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Ucrania Pais de publicación: Polonia