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Long-term exposure to fine particulate matter constituents in relation to chronic kidney disease: evidence from a large population-based study in China.
Dai, Yucen; Yin, Jianzhong; Li, Sicheng; Li, Jiawei; Han, Xinyu; Deji, Quzong; Pengcuo, Ciren; Liu, Leilei; Yu, Zhimiao; Chen, Liling; Xie, Linshen; Guo, Bing; Zhao, Xing.
Afiliación
  • Dai Y; West China School of Public Health and West China Fourth Hospital, Sichuan University, No.17, Section 3, South Renmin Road, Chengdu, 610041, Sichuan Province, China.
  • Yin J; School of Public Health, Kunming Medical University, Kunming, China.
  • Li S; Baoshan College of Traditional Chinese Medicine, Baoshan, China.
  • Li J; West China School of Public Health and West China Fourth Hospital, Sichuan University, No.17, Section 3, South Renmin Road, Chengdu, 610041, Sichuan Province, China.
  • Han X; West China School of Public Health and West China Fourth Hospital, Sichuan University, No.17, Section 3, South Renmin Road, Chengdu, 610041, Sichuan Province, China.
  • Deji Q; West China School of Public Health and West China Fourth Hospital, Sichuan University, No.17, Section 3, South Renmin Road, Chengdu, 610041, Sichuan Province, China.
  • Pengcuo C; Tibet University, Lhasa, China.
  • Liu L; Tibet Center for Disease Control and Prevention CN, Lhasa, China.
  • Yu Z; School of Public Health the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China.
  • Chen L; Chengdu Center for Disease Control and Prevention, Chengdu, China.
  • Xie L; Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China.
  • Guo B; West China School of Public Health and West China Fourth Hospital, Sichuan University, No.17, Section 3, South Renmin Road, Chengdu, 610041, Sichuan Province, China. linshenxie@163.com.
  • Zhao X; West China School of Public Health and West China Fourth Hospital, Sichuan University, No.17, Section 3, South Renmin Road, Chengdu, 610041, Sichuan Province, China. guobing0111@foxmail.com.
Environ Geochem Health ; 46(5): 174, 2024 Apr 09.
Article en En | MEDLINE | ID: mdl-38592609
ABSTRACT
The effects of long-term exposure to fine particulate matter (PM2.5) constituents on chronic kidney disease (CKD) are not fully known. This study sought to examine the association between long-term exposure to major PM2.5 constituents and CKD and look for potential constituents contributing substantially to CKD. This study included 81,137 adults from the 2018 to 2019 baseline survey of China Multi-Ethnic Cohort. CKD was defined by the estimated glomerular filtration rate. Exposure concentration data of 7 major PM2.5 constituents were assessed by satellite remote sensing. Logistic regression models were used to estimate the effect of each PM2.5 constituent exposure on CKD. The weighted quantile sum regression was used to estimate the effect of mixed exposure to all constituents. PM2.5 constituents had positive correlations with CKD (per standard deviation increase), with ORs (95% CIs) of 1.20 (1.02-1.41) for black carbon, 1.27 (1.07-1.51) for ammonium, 1.29 (1.08-1.55) for nitrate, 1.20 (1.01-1.43) for organic matter, 1.25 (1.06-1.46) for sulfate, 1.30 (1.11-1.54) for soil particles, and 1.63 (1.39-1.91) for sea salt. Mixed exposure to all constituents was positively associated with CKD (1.68, 1.32-2.11). Sea salt was the constituent with the largest weight (0.36), which suggested its importance in the PM2.5-CKD association, followed by nitrate (0.32), organic matter (0.18), soil particles (0.10), ammonium (0.03), BC (0.01). Sulfate had the least weight (< 0.01). Long-term exposure to PM2.5 sea salt and nitrate may contribute more than other constituents in increasing CKD risk, providing new evidence and insights for PM2.5-CKD mechanism research and air pollution control strategy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Compuestos de Amonio Límite: Adult / Humans País/Región como asunto: Asia Idioma: En Revista: Environ Geochem Health Asunto de la revista: QUIMICA / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Compuestos de Amonio Límite: Adult / Humans País/Región como asunto: Asia Idioma: En Revista: Environ Geochem Health Asunto de la revista: QUIMICA / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos