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Short- and Long-Term Outcomes of Neoadjuvant Chemoradiotherapy Followed by Pancreatoduodenectomy in Elderly Patients with Resectable and Borderline Resectable Pancreatic Cancer: A Retrospective Study.
Suto, Hironobu; Fuke, Takuro; Matsukawa, Hiroyuki; Ando, Yasuhisa; Oshima, Minoru; Nagao, Mina; Takahashi, Shigeo; Shibata, Toru; Yamana, Hiroki; Kamada, Hideki; Kobara, Hideki; Okuyama, Hiroyuki; Kumamoto, Kensuke; Okano, Keiichi.
Afiliación
  • Suto H; Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Miki 761-0793, Kagawa, Japan.
  • Fuke T; Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Miki 761-0793, Kagawa, Japan.
  • Matsukawa H; Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Miki 761-0793, Kagawa, Japan.
  • Ando Y; Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Miki 761-0793, Kagawa, Japan.
  • Oshima M; Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Miki 761-0793, Kagawa, Japan.
  • Nagao M; Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Miki 761-0793, Kagawa, Japan.
  • Takahashi S; Department of Molecular Oncologic Pathology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Miki 761-0793, Kagawa, Japan.
  • Shibata T; Department of Radiation Oncology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Miki 761-0793, Kagawa, Japan.
  • Yamana H; Department of Radiation Oncology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Miki 761-0793, Kagawa, Japan.
  • Kamada H; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Miki 761-0793, Kagawa, Japan.
  • Kobara H; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Miki 761-0793, Kagawa, Japan.
  • Okuyama H; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Miki 761-0793, Kagawa, Japan.
  • Kumamoto K; Department of Clinical Oncology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Miki 761-0793, Kagawa, Japan.
  • Okano K; Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Miki 761-0793, Kagawa, Japan.
J Clin Med ; 13(5)2024 Feb 21.
Article en En | MEDLINE | ID: mdl-38592055
ABSTRACT

Background:

The efficacy of neoadjuvant chemoradiotherapy (NACRT) followed by pancreatoduodenectomy (PD) in elderly patients with pancreatic ductal adenocarcinoma (PDAC) remains unclear.

Methods:

This retrospective analysis of prospectively collected data examined the effect of NACRT followed by PD in elderly patients with PDAC. A total of 112 patients with resectable (R-) and borderline resectable (BR-) PDAC, who were planned for PD and received NACRT between 2009 and 2022, were assessed. Changes induced by NACRT, surgical outcomes, nutritional status, renal and endocrine functions, and prognosis were compared between elderly (≥75 years, n = 43) and non-elderly (<75 years, n = 69) patients over two years following PD.

Results:

Completion and adverse event rates during NACRT, nutritional status, renal function, endocrine function over two years postoperatively, and prognosis did not significantly differ between the two groups. Low prognostic index after NACRT and the absence of postoperative adjuvant chemotherapy may be adverse prognostic indicators for elderly patients undergoing NACRT for R- and BR-PDAC.

Conclusions:

Despite a higher incidence of postoperative complications, NACRT followed by PD can be safely performed in elderly patients, resulting in a prognosis similar to that in non-elderly patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza