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Whole brain pattern of iron accumulation in REM sleep behavior disorder.
Varga, Zsoka; Keller, Jiri; Robinson, Simon Daniel; Serranova, Tereza; Nepozitek, Jiri; Zogala, David; Trnka, Jiri; Ruzicka, Evzen; Sonka, Karel; Dusek, Petr.
Afiliación
  • Varga Z; Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
  • Keller J; Radiodiagnostic Department, Na Homolce Hospital, Prague, Czech Republic.
  • Robinson SD; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Austria.
  • Serranova T; Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
  • Nepozitek J; Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
  • Zogala D; Department of Nuclear Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
  • Trnka J; Department of Nuclear Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
  • Ruzicka E; Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
  • Sonka K; Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
  • Dusek P; Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
Hum Brain Mapp ; 45(5): e26675, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38590155
ABSTRACT
Isolated REM sleep behavior disorder (iRBD) is an early stage of synucleinopathy with most patients progressing to Parkinson's disease (PD) or related conditions. Quantitative susceptibility mapping (QSM) in PD has identified pathological iron accumulation in the substantia nigra (SN) and variably also in basal ganglia and cortex. Analyzing whole-brain QSM across iRBD, PD, and healthy controls (HC) may help to ascertain the extent of neurodegeneration in prodromal synucleinopathy. 70 de novo PD patients, 70 iRBD patients, and 60 HCs underwent 3 T MRI. T1 and susceptibility-weighted images were acquired and processed to space standardized QSM. Voxel-based analyses of grey matter magnetic susceptibility differences comparing all groups were performed on the whole brain and upper brainstem levels with the statistical threshold set at family-wise error-corrected p-values <.05. Whole-brain analysis showed increased susceptibility in the bilateral fronto-parietal cortex of iRBD patients compared to both PD and HC. This was not associated with cortical thinning according to the cortical thickness analysis. Compared to iRBD, PD patients had increased susceptibility in the left amygdala and hippocampal region. Upper brainstem analysis revealed increased susceptibility within the bilateral SN for both PD and iRBD compared to HC; changes were located predominantly in nigrosome 1 in the former and nigrosome 2 in the latter group. In the iRBD group, abnormal dopamine transporter SPECT was associated with increased susceptibility in nigrosome 1. iRBD patients display greater fronto-parietal cortex involvement than incidental early-stage PD cohort indicating more widespread subclinical neuropathology. Dopaminergic degeneration in the substantia nigra is paralleled by susceptibility increase, mainly in nigrosome 1.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Trastorno de la Conducta del Sueño REM / Sinucleinopatías Límite: Humans Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Trastorno de la Conducta del Sueño REM / Sinucleinopatías Límite: Humans Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos